Francesco Orofino

TL;DR: A batch of a promising candidate for optimization studies turned out to be a mixture containing two unknown species with a better biological activity than the pure compound, and this serendipitous discovery led to investigate the chemical nature of the unknown components of the mixture.

TL;DR: The research highlights the low in vivo toxicity profile of BM1, its affinity for the renal system in rats and its good absorption, distribution, metabolism, and excretion (ADME) features, which make BM1 and its derivatives a novel promising antifungal class.

TL;DR: A computational virtual screening procedure for the repurposing of commercial drugs available in the DrugBank database as inhibitors of the SARS-CoV-2 main protease was used, highlighting five interesting drugs that showed a comparable or higher docking score compared to the crystallographic compound and maintained the protein binding during the MD runs.

TL;DR: The data suggest that chitinase represent at least one of the main target of macrocyclic amidinoureas, and a novel macro cyclic derivative has been produced, specifically designed to increase the inhibition of the chitInase.

TL;DR: Gold-nanoparticle (AuNP)-conjugated drugs represent a promising and innovative antitumor therapeutic approach and it was demonstrated that AuNPs had a basal radiosensitization ability and that auNPs-SI306, when used in combination with RT, were more effective in inhibiting tumor cell growth with respect to AuNps and free SI306.