F
Fabienne Danhier
Researcher at Université catholique de Louvain
Publications - 48
Citations - 10158
Fabienne Danhier is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: PLGA & Drug delivery. The author has an hindex of 29, co-authored 48 publications receiving 8461 citations.
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Journal ArticleDOI
PLGA-based nanoparticles: An overview of biomedical applications
Fabienne Danhier,Eduardo Ansorena,Joana M. Silva,Joana M. Silva,Régis Coco,Aude Le Breton,Véronique Préat +6 more
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
TL;DR: Delivery of conventional chemotherapeutic anti-cancer drugs is mainly discussed and exploitation and the understanding of these characteristics to design new drug delivery systems targeting the tumor are focused on.
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To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
TL;DR: The basic rationale of the design and development of nanomedicines in cancer therapy is failing making it necessary to stop claiming efficacy gains via the EPR effect, while tumor targeting cannot be proved in the clinic, so it is probably time to dethrone the E PR effect.
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RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis.
TL;DR: This review aims to particularly highlight the position of RGD-based nanoparticles in cancer therapy and imaging and the binding of the RGD peptide to this integrin.
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Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation
Fabienne Danhier,Nathalie Lecouturier,Benoît Vroman,Christine Jérôme,Jacqueline Marchand-Brynaert,Olivier Feron,Véronique Préat +6 more
TL;DR: PTX-loaded nanoparticles showed greater tumor growth inhibition effect in vivo on TLT tumor, compared with Taxol, and may be considered as an effective anticancer drug delivery system for cancer chemotherapy.