Showing papers in "Journal of Controlled Release in 2009"

TL;DR: Evidence is provided that SLNs are valuable as an oral delivery carrier to enhance the absorption of a poorly water soluble drug, quercetin.

TL;DR: PTX-loaded nanoparticles showed greater tumor growth inhibition effect in vivo on TLT tumor, compared with Taxol, and may be considered as an effective anticancer drug delivery system for cancer chemotherapy.

TL;DR: Given such favorable properties including low toxicity, biocompatibility, and fast uptake by several nondestructive endocytic pathways, the HGC nanoparticles may serve as a versatile carrier for the intracellular delivery of therapeutic agents.

TL;DR: The review article is an overview of OST encompassing materials used in OST, critical manufacturing aspects, applications, commercial technologies and future business prospects of this technology.

TL;DR: No therapeutic effect from the nanodroplet/ultrasound combination was observed without the drug, indicating that therapeutic effect was caused by the ultrasound-enhanced chemotherapeutic action of the tumor-targeted drug, rather than the mechanical or thermal action of ultrasound itself.

TL;DR: DNPs have been shown to be amenable to targeting of the drug to the site of action, leading to a decreases in the dose required and a decrease in side effects, which makes them a novel polymeric drug delivery device, which fulfils the requirements for ophthalmic application.

TL;DR: A novel silk microsphere/scaffold system offers a new option for the delivery of multiple growth factors with spatial control in a 3D culture environment for both understanding natural tissue growth process and in vitro engineering complex tissue constructs.

TL;DR: Findings indicate that nanoparticles with covalently bound apolipoprotein E are taken up into the cerebral endothelium by an endocytic mechanism followed by transcytosis into brain parenchyma.

TL;DR: A pH-responsive carrier designed to mediate endosomal release shows significant promise for the intracellular delivery of siRNA.

TL;DR: In vivo, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach and is demonstrated to be more effective in vitro and in vivo than taxol.

TL;DR: In vivo body distribution data confirmed high specificity of the proposed targeting delivery approach which created the basis for the prevention of adverse side effects of the treatment on healthy organs, and efficient gene silencing.

TL;DR: The comprehensive analysis of rheological and mechanical properties will provide an insight into the potential usage of thixotropic formulations as drug delivery systems.

TL;DR: The significant in vitro and in vivo results suggest that Lf-NP is a promising brain drug delivery system with low toxicity.

TL;DR: New information emerging regarding the intratumoral distribution, and tumor penetration of BCMs and other nanosystems in vivo, by non-invasive image-based assessment, has the potential to revolutionize the understanding and current approach to drug delivery in this field.

TL;DR: It was shown that the rapid gelation achieved by an optimal concentration of HRP could effectively encapsulate the proteins within the hydrogel network and thus prevented the undesired leakage of proteins into the surrounding tissues after injection.

TL;DR: Results suggest that the use of targeted, dual agent nanoparticles delivering a combination of P-gp modulator and anticancer drug is a very promising approach to overcome tumor drug resistance.

TL;DR: This work describes how applying data-mining algorithms on a data bank based on Barenholz's laboratory's 15 years of liposome research experience on remote loading of 9 different drugs enabled it to build a model that relates drug physicochemical properties and loading conditions to loading efficiency.

TL;DR: A modality for the release of drugs from liposomes in vivo using LFUS is presented and the effect of LFUS-induced localized drug release on the therapeutic efficacy was tested on BALB/c mice with C26 colon adenocarcinoma tumors in a footpad.

TL;DR: A novel tissue engineering scaffold with the capability of controlled releasing BMP-2-derived synthetic peptide is developed and offers a new delivery method of growth factors and a novel scaffold design for bone regeneration.

TL;DR: The ultrafiltration and dialysis studies revealed that the release of 80% of docetaxel was released from the microemulsions within 12 h in vitro, and the oral bioavailability rose dramatically compared to that of the orally administered Taxotere.

TL;DR: In vivo proof of concept study in rats showed that after subcutaneous administration of phytantriol and glyceryl monooleate-based bicontinuous cubic and inverse hexagonal nanostructures, the changes in nanostructure induced by application of a heat or cool pack at the injection site stimulated changes in drug release from the matrix anticipated from in vitro release behaviour, demonstrating the potential utility of these systems as 'on demand' drug release delivery vehicles.

TL;DR: The new NP preparation technique, double emulsion solvent diffusion (DES-D), resulted in improved formulation characteristics including smaller size, lower size distribution, higher encapsulation yield, and more biocompatible ingredients in comparison to classical methods.

TL;DR: The results point to a potential of novel polymer micelles with cross-linked ionic cores to be attractive carriers for the delivery of DOX.

TL;DR: Paclitaxel-loaded LNCs improved permeability of Ptx across intestinal epithelium compared with free Ptx or Taxol by a factor of 3.5 and transmission electronic microscopy showed the presence of nano-objects on the basolateral side of the Caco-2 cell monolayers when LNC's were applied on the apical side.

TL;DR: It is found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically relevant doses.

TL;DR: Data demonstrate that introduction of both of a pH-sensitive fusogenic GALA peptide and PPD into the MEND facilitates nanoparticle endosomal escape, thereby enhancing the efficiency of siRNA delivery and gene silencing.

TL;DR: This article will first give a brief overview of the physical and biological properties of chitosan, then, with a special focus on plasmid DNA delivery, a detailed discussion of the latest advances in chitOSan-mediated NA transfer.

TL;DR: No recrystallization of either drug in the 1:1 co-milled sample was observed during dissolution testing, with naproxen and cimetidine having a four and two times higher intrinsic dissolution rate, respectively, compared to their crystalline counterparts.

TL;DR: A wide range of orotransmucosal routes being potentially useful for transmucosal drug delivery are overviewed to remind us of the success achieved with these systems and the latest advancement in the field.

TL;DR: A series of physical hydrogel blends designed for independent delivery of one or more drugs, from 1 to 28 days, for ultimate application in spinal cord injury repair strategies are reported.