In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.

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Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases; for example, by allowing the targeted delivery of a drug to particular subsets of cells. However, so far, such nanoparticles have not proved capable of surmounting all of the biological barriers required to achieve this goal. Nevertheless, advances in nanoparticle engineering, as well as advances in understanding the importance of nanoparticle characteristics such as size, shape and surface properties for biological interactions, are creating new opportunities for the development of nanoparticles for therapeutic applications. This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.

Strategies in the design of nanoparticles for therapeutic applications

Biodegradable polymeric nanoparticles based drug delivery systems

PLGA-based nanoparticles: An overview of biomedical applications

https://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2010-2.pdf

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

http://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2009-1.pdf

Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation

http://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2009-3.pdf

Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel

Bioadhesive nanoparticles of fungal chitosan for oral DNA delivery.

http://www.farm.ucl.ac.be/Full-texts-FARM/Mathy-2003-1.pdf

On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography

http://www.farm.ucl.ac.be/Full-texts-FARM/Vroman-2007-1.pdf

Benoît Vroman

Papers

Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation

Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel

Bioadhesive nanoparticles of fungal chitosan for oral DNA delivery.

On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography

Copolymers of epsilon-caprolactone and quaternized epsilon-caprolactone as gene carriers.