Fábio G. Teixeira

TL;DR: Considering their protective action in lesioned sites, MSCs’ secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutic strategies in human clinical trials.

TL;DR: The studies reveal that MSCs-derived exosomes hold a great potential for cell-free therapies that are safer and easier to manipulate than cell-based products and the molecular mechanisms underlying these effects are discussed.

TL;DR: It is concluded that the use of human MSC secretome alone was able to partially revert the motor phenotype and the neuronal structure of 6‐OHDA PD animals, indicating that the human M SC secretome could represent a novel therapeutic for the treatment of PD.

TL;DR: This chapter aims at introducing the reader to the concepts and techniques of TERM by explaining how TERM have evolved and merged into TERM, followed by a short overview of some of its key aspects such as the combinations of scaffolds with cells and nanomedicine, scaffold processing, and new paradigms of the use of stem cells for tissue repair/regeneration.

TL;DR: A comprehensive review on MSCs populations of the WJ and how these cell populations may be used for future applications in CNS regenerative medicine is made by critically reviewing the work that has been performed so far.