António J. Salgado

TL;DR: The present review pretends to give an exhaustive overview on all components needed for making bone tissue engineering a successful therapy, going from materials to scaffolds and from cells to tissue engineering strategies that will lead to "engineered" bone.

TL;DR: An extensive overview of SCI research, as well as its clinical component, is provided, covering areas from physiology and anatomy of the spinal cord, neuropathology of the SCI, current clinical options, neuronal plasticity after SCI and a variety of promising neuroprotective, cell-based and combinatorial therapeutic approaches that have recently moved, or are close to clinical testing.

TL;DR: It is aim, in the present review, to make a comprehensive analysis of the literature relating to the ASCs' secretome and its relevance to the immune and central nervous system, vascularization and cardiac regeneration.

TL;DR: The cell culture studies with SaOs-2 human osteoblast-like cell line and rat bone marrow stromal cells demonstrated that presence of nanofibers influenced cell shape and cytoskeletal organization of the cells on the nano/micro combined scaffolds.

TL;DR: Considering their protective action in lesioned sites, MSCs’ secretome might also improve the integration of local progenitor cells in neuroregeneration processes, opening a door for their future use as therapeutic strategies in human clinical trials.