Fabrizio Trinchese

TL;DR: It is demonstrated that brief treatment with the phosphodiesterase 4 inhibitor rolipram ameliorates deficits in both long-term potentiation (LTP) and contextual learning in the double-transgenic mice and this beneficial effect can be extended beyond the duration of the administration.

TL;DR: Interestingly, reduced LTP paralleled plaque appearance and increased Aβ levels and abnormal short‐term memory (working memory) and progression of LTP impairment correlated with the deterioration of working memory, suggesting that percentage of potentiation might be an indicator of the cognitive decline and disease progression in the APP/PS1 mice.

TL;DR: It is indicated that RAGE is a cofactor for Aβ‐induced neuronal perturbation in a model of Alzheimer's‐type pathology, and its potential as a therapeutic target to ameliorate cellular dysfunction is suggested.

TL;DR: In this article, the role of the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP/CGMP-dependent protein kinase (cGK)/cAMP-responsive element-binding protein (CREB) cascade was analyzed.

TL;DR: Beneficial effects of the calpain inhibitors were associated with restoration of normal phosphorylation levels of the transcription factor CREB and involved redistribution of the synaptic protein synapsin I, suggesting that calpain inhibition may prove useful in the alleviation of memory loss in AD.