F
Fan Zhang
Researcher at Illumina
Publications - 30
Citations - 3704
Fan Zhang is an academic researcher from Illumina. The author has contributed to research in topics: Lipid bilayer fusion & Cell type. The author has an hindex of 17, co-authored 24 publications receiving 2117 citations. Previous affiliations of Fan Zhang include Iowa State University & Scripps Research Institute.
Papers
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Journal ArticleDOI
The single-cell transcriptional landscape of mammalian organogenesis
Junyue Cao,Malte Spielmann,Xiaojie Qiu,Xingfan Huang,Daniel M. Ibrahim,Daniel M. Ibrahim,Andrew J. Hill,Fan Zhang,Stefan Mundlos,Stefan Mundlos,Lena Christiansen,Frank J. Steemers,Cole Trapnell,Jay Shendure +13 more
TL;DR: A cell atlas of mouse organogenesis provides a global view of developmental processes occurring during this critical period, including focused analyses of the apical ectodermal ridge, limb mesenchyme and skeletal muscle.
Journal ArticleDOI
A human cell atlas of fetal gene expression
Junyue Cao,Diana R. O’Day,Hannah A. Pliner,Paul D. Kingsley,Mei Deng,Riza M. Daza,Michael Zager,Kimberly A. Aldinger,Kimberly A. Aldinger,Ronnie Blecher-Gonen,Fan Zhang,Malte Spielmann,Malte Spielmann,James Palis,Dan Doherty,Dan Doherty,Frank J. Steemers,Ian A. Glass,Ian A. Glass,Cole Trapnell,Jay Shendure +20 more
TL;DR: A pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples, which generates comprehensive atlases of early human development.
Journal ArticleDOI
Hemifusion in SNARE-mediated membrane fusion.
TL;DR: Results show that SNARE-mediated fusion can transit through a hemifusion intermediate and be detected with wild-type SNAREs when low protein concentrations were reconstituted.
Journal ArticleDOI
Multiple intermediates in SNARE-induced membrane fusion
TL;DR: Real-time observation of lipid-mixing dynamics in a single fusion event between a pair of SNARE-reconstituted liposomes reveals multiple intermediate states characterized by discrete values of FRET between membrane-bound fluorophores.
Journal ArticleDOI
A human cell atlas of fetal chromatin accessibility
Silvia Domcke,Andrew J. Hill,Riza M. Daza,Junyue Cao,Diana R. O’Day,Hannah A. Pliner,Kimberly A. Aldinger,Kimberly A. Aldinger,Dmitry K. Pokholok,Fan Zhang,Jennifer H. Milbank,Michael Zager,Ian A. Glass,Ian A. Glass,Frank J. Steemers,Dan Doherty,Dan Doherty,Cole Trapnell,Darren A. Cusanovich,Darren A. Cusanovich,Jay Shendure +20 more
TL;DR: An improved assay using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples, which identifies fetal-specific cell subtypes and nominate POU2F1 as a potential regulator of excitatory neuron development.