J
James Palis
Researcher at University of Rochester Medical Center
Publications - 156
Citations - 13722
James Palis is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Yolk sac & Erythropoiesis. The author has an hindex of 52, co-authored 147 publications receiving 12252 citations. Previous affiliations of James Palis include University of Rochester.
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Journal ArticleDOI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
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Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.
TL;DR: The pattern of development suggests that definitive hematopoietic progenitors arise in the yolk sac, migrate through the bloodstream and seed the fetal liver to rapidly initiate the first phase of intraembryonic hematoiesis.
Journal ArticleDOI
Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.
TL;DR: Detailed mapping studies reveal that haemangioblasts are found at highest frequency in the posterior region of the primitive streak, indicating that initial stages of haematopoietic and vascular commitment occur before blood island development in the yolk sac.
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Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.
TL;DR: Roles for chemokine signaling in multiple embryogenic events are suggested, particularly at earlier times (E7.5 and E8.5), with an optimum dose similar to that found for adult hematopoietic cells and was dependent on the presence of SDF-1 in a gradient.
Journal ArticleDOI
Yolk-sac hematopoiesis: The first blood cells of mouse and man
James Palis,Mervin C. Yoder +1 more
TL;DR: The yolk sac is the sole site of embryonic erythropoiesis, however, definitive erythroid, myeloid, and multipotential progenitors also originate in the yolks, and the relationship between these progenites and the "embryonic" hematopoietic stem cell has not been elucidated.