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Xingfan Huang
Researcher at University of Washington
Publications - 19
Citations - 4974
Xingfan Huang is an academic researcher from University of Washington. The author has contributed to research in topics: Chromatin & Cohesin. The author has an hindex of 12, co-authored 14 publications receiving 2668 citations. Previous affiliations of Xingfan Huang include Baylor College of Medicine & Rice University.
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Journal ArticleDOI
The single-cell transcriptional landscape of mammalian organogenesis
Junyue Cao,Malte Spielmann,Xiaojie Qiu,Xingfan Huang,Daniel M. Ibrahim,Daniel M. Ibrahim,Andrew J. Hill,Fan Zhang,Stefan Mundlos,Stefan Mundlos,Lena Christiansen,Frank J. Steemers,Cole Trapnell,Jay Shendure +13 more
TL;DR: A cell atlas of mouse organogenesis provides a global view of developmental processes occurring during this critical period, including focused analyses of the apical ectodermal ridge, limb mesenchyme and skeletal muscle.
Journal ArticleDOI
Cohesin Loss Eliminates All Loop Domains
Suhas S.P. Rao,Suhas S.P. Rao,Su Chen Huang,Brian Glenn St Hilaire,Brian Glenn St Hilaire,Jesse M. Engreitz,Elizabeth M. Perez,Kyong-Rim Kieffer-Kwon,Adrian L. Sanborn,Adrian L. Sanborn,Adrian L. Sanborn,Sarah E. Johnstone,Sarah E. Johnstone,Gavin D. Bascom,Ivan D. Bochkov,Xingfan Huang,Xingfan Huang,Muhammad S. Shamim,Muhammad S. Shamim,Jaeweon Shin,Jaeweon Shin,Douglass Turner,Douglass Turner,Ziyi Ye,Ziyi Ye,Arina D. Omer,James T. Robinson,James T. Robinson,James T. Robinson,Tamar Schlick,Tamar Schlick,Tamar Schlick,Bradley E. Bernstein,Bradley E. Bernstein,Rafael Casellas,Eric S. Lander,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +38 more
TL;DR: In this paper, the effects of degrading cohesin were explored, showing that loop domains can be eliminated and re-formed in under an hour, consistent with a model where loop extrusion is rapid.
Journal ArticleDOI
A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility
Darren A. Cusanovich,Andrew J. Hill,Delasa Aghamirzaie,Riza M. Daza,Hannah A. Pliner,Joel B. Berletch,Galina N. Filippova,Xingfan Huang,Lena Christiansen,William S DeWitt,Choli Lee,Samuel G. Regalado,David F. Read,Frank J. Steemers,Christine M. Disteche,Cole Trapnell,Jay Shendure,Jay Shendure +17 more
TL;DR: By intersecting mouse chromatin accessibility with human genome-wide association summary statistics, this work identifies cell-type-specific enrichments of the heritability signal for hundreds of complex traits.
Journal ArticleDOI
Accurate classification of BRCA1 variants with saturation genome editing.
Gregory M. Findlay,Riza M. Daza,Beth Martin,Melissa D. Zhang,Anh Leith,Molly Gasperini,Joseph D. Janizek,Xingfan Huang,Lea M. Starita,Jay Shendure +9 more
TL;DR: Saturation genome editing is used to assay 96.5% of all possible single-nucleotide variants in 13 exons that encode functionally critical domains of BRCA1, and functional effects for nearly 4,000 SNVs are bimodally distributed and almost perfectly concordant with established assessments of pathogenicity.
Cohesin Loss Eliminates All Loop Domains
Suhas S.P. Rao,Su-Chen Huang,Brian Glenn St Hilaire,Jesse M. Engreitz,Elizabeth M. Perez,Kyong-Rim Kieffer-Kwon,Adrian L. Sanborn,Sarah E. Johnstone,Gavin D. Bascom,Ivan D. Bochkov,Xingfan Huang,Muhammad S. Shamim,Jaeweon Shin,Douglass Turner,Ziyi Ye,Arina D. Omer,James T. Robinson,Tamar Schlick,Bradley E. Bernstein,Rafael Casellas,Erez Lieberman Aiden,Eric S. Lander +21 more
TL;DR: All loop domains are eliminated, but neither compartment domains nor histone marks are affected, and many megabase-sized loops recovered in under an hour, consistent with a model where loop extrusion is rapid.