F
Fanny Guzmán
Researcher at Pontifical Catholic University of Valparaíso
Publications - 164
Citations - 2874
Fanny Guzmán is an academic researcher from Pontifical Catholic University of Valparaíso. The author has contributed to research in topics: Peptide & Epitope. The author has an hindex of 28, co-authored 138 publications receiving 2328 citations. Previous affiliations of Fanny Guzmán include Valparaiso University & Sao Paulo State University.
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Journal ArticleDOI
Understanding the antimicrobial properties/activity of an 11-residue Lys homopeptide by alanine and proline scan
Patricio Carvajal-Rondanelli,Mónica Aróstica,Claudio Alvarez,Claudia Ojeda,Fernando Albericio,Luis F. Aguilar,Sergio H. Marshall,Fanny Guzmán +7 more
TL;DR: Results indicate that the PPII secondary structure of K11 is stabilized by the interaction of the peptide with negatively charged phospholipids in the bacterial membrane, though not being the sole determinant for its antimicrobial activity.
Journal ArticleDOI
Design and activity of novel lactoferrampin analogues against O157:H7 enterohemorrhagic escherichia coli
Jenniffer Cruz,Claudia Ortiz,Fanny Guzmán,Constanza Cárdenas,Roberto Fernandez-Lafuente,Rodrigo Torres +5 more
TL;DR: Three analogues of LFampin 265-284 are designed based on the distribution of cationic groups, hydrophobicity, size, and sequence, and exhibited a significant increase in antimicrobial activity by counting colony forming units against EHEC O157:H7 compared to native LFamp in 265- 284.
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Chemical Synthesis and In Vitro Evaluation of a Phage Display-Derived Peptide Active against Infectious Salmon Anemia Virus.
TL;DR: An alternative treatment approach based on interfering peptides selected from a phage display library is described, which efficiently impairs ISAV infection in vitro by specifically blocking hemagglutinin-esterase, a pivotal surface protein of this virus.
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Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
Fanny Guzmán,Adriana Gauna,Tanya Román,Omar Luna,Omar Luna,Omar Luna,Claudio Alvarez,Claudia Pareja-Barrueto,Luis Mercado,Fernando Albericio,Fernando Albericio,Fernando Albericio,Constanza Cárdenas +12 more
TL;DR: In this article, a protocol for the multiple Fmoc solid-phase peptide synthesis in tea bags, where reagent recycling steps are included, is presented, which turns the process into a framework of circular economy, without affecting the quality of the products obtained.
Journal ArticleDOI
Inhibitory effect of short cationic homopeptides against Gram-negative bacteria
Patricio Carvajal-Rondanelli,Mónica Aróstica,Sergio H. Marshall,Fernando Albericio,Claudio Alvarez,Claudia Ojeda,Luis F. Aguilar,Fanny Guzmán +7 more
TL;DR: Gram-negative bacteria were comparatively more resistant than Gram-positive bacteria to Lys homopeptides with an odd number of residues, but exhibited a similar inhibition pattern than on Gram- positive bacteria.