Fanyun Kong

TL;DR: It is elucidated that miR‐409‐3p and miR-1896, as co‐upregulated microRNAs in activated astrocytes and in EAE mice, targeted suppressor of cytokine signaling proteins 3 (SOCS3), which may be a therapeutic target for treating MS and neuroinflammation.

TL;DR: Hepatitis B virus X protein (HBx) could upregulate LASP-1 through PI3-K pathway to promote the proliferation and migration of hepatoma cells and was demonstrated to be able to suppress hepatocellular cells proliferation and Migration.

TL;DR: HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression through inhibition of JNKs and activation of Fas/FasL proteins.

TL;DR: It is demonstrated that increased apoptosis induced by TRAIL is associated with increased expression of DR5 that mediated by HBX through NF-κB pathway, providing a critical insight into the mechanism of hepatocyte apoptosis mediated byHBX in HBV infection.

TL;DR: A better understanding of the HBV-UPS interaction could provide novel insight into the mechanisms that are involved in viral replication and pathogenesis and help to develop potential treatment strategies targeting the UPS.