Current approaches and challenges for the metabolite profiling of complex natural extracts

In the last few years more and more studies on the biological properties of essential oils have been published and it seemed worthwhile to compile the studies of 2009, 2008 and the second part of 2007. Such an overview covering the scientific literature mainly from 2000 onwards, up to the first half of the year 2007, has been published recently. The focus of this overview lies on the anti-nociceptive, anticancer, anti-inflammatory, penetration-enhancing, insect repellent, antiviral and antioxidative properties of essential oils. Many essential oils have been used for centuries in folk medicine and in recent years the biological properties of various essential oils have been proved by a number of studies. Their use in the treatment of pain, inflammation, viral diseases and cancer and their potential to enhance the penetration of other drugs, their insect repellent activity and their antioxidative effects were confirmed. Nonetheless, more studies are necessary to analyse the biological properties of other essential oils or to prove their mechanism of action. Copyright © 2010 John Wiley & Sons, Ltd.

Biological properties of essential oils: an updated review

Stressed food – The impact of abiotic environmental stresses on crop quality

Introduction: The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcomes observed with the commercially available anti-diabetic drugs have led to the investigation of new therapeutic approaches focused on controlling postprandrial glucose levels. The use of carbohydrate digestive enzyme inhibitors from natural resources could be a possible strategy to block dietary carbohydrate absorption with less adverse effects than synthetic drugs. Areas covered: This review covers the latest evidence regarding in vitro and in vivo studies in relation to pancreatic alpha-amylase inhibitors of plant origin, and presents bioactive compounds of phenolic nature that exhibit anti-amylase activity. Expert opinion: Pancreatic alpha-amylase inhibitors from traditional plant extracts are a promising tool for diabetes treatment. Many studies have confirmed the alpha-amylase inhibitory activity of plants and their bioactive compounds in vitro, but few studies corroborate these findings in rodents an...

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Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

https://pubs.rsc.org/en/content/articlepdf/2013/np/c3np20106f

Natural product isolation – how to get from biological material to pure compounds

Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss.

https://profdoc.um.ac.ir/articles/a/1009422.pdf

Effect of irrigation frequency and planting density on herbage biomass and oil production of thyme (Thymus vulgaris) and hyssop (Hyssopus officinalis)

Yield and seed quality of Plantago ovata and Nigella sativa under different irrigation treatments

Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity

In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and alpha-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC(50) 2.26 microL/mL. Interesting cholinesterase inhibitory activity was also found with IC(50) values of 0.32 and 0.29 microL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC(50) value of 165 microg/mL. The absence of cytotoxicity at 1000 microg/mL was evaluated by MTT assay in 142BR cells.

Farsad Nadjafi

Papers

Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss.

Effect of irrigation frequency and planting density on herbage biomass and oil production of thyme (Thymus vulgaris) and hyssop (Hyssopus officinalis)

Yield and seed quality of Plantago ovata and Nigella sativa under different irrigation treatments

Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity

In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease.