F
Farshid Dayyani
Researcher at University of California, Irvine
Publications - 124
Citations - 4100
Farshid Dayyani is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 26, co-authored 84 publications receiving 3489 citations. Previous affiliations of Farshid Dayyani include University of Leicester & Harvard University.
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Journal ArticleDOI
The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF
Kai-Uwe Belge,Farshid Dayyani,Alexia Horelt,Maciej Siedlar,Marion Frankenberger,Bernhard Frankenberger,Terje Espevik,Löms Ziegler-Heitbrock +7 more
TL;DR: The minor population of CD14+CD16+ monocytes are major producers of TNF in human blood, and the median fluorescence intensity for Toll-like receptor 2 cell surface protein was found 2-fold higher on CD14-CD16-DR++ monocytes, which may explain, in part, the higher Pam3Cys-induced TNF production by these cells.
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Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)
TL;DR: HPV+ HNSCC are established as a separate biologic entity and Prospective trials are needed to establish the optimal therapy for HPV+ H NSCC.
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Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
Muling Mao,Feng Tian,John M. Mariadason,Chun C. Tsao,Robert Lemos,Farshid Dayyani,Y.N. Vashisht Gopal,Zhi-Qin Jiang,Ignacio I. Wistuba,Xi M. Tang,William G. Bornman,Gideon Bollag,Gordon B. Mills,Garth Powis,Jayesh Desai,Gary E. Gallick,Michael A. Davies,Scott Kopetz +17 more
TL;DR: It is shown that activation of the PI3K/AKT pathway is a mechanism of both innate and acquired resistance to BRAF inhibitors in BRAFV600E CRC and suggest combinatorial approaches to improve outcomes in this poor prognosis subset of patients.
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Selective mobilization of CD14(+)CD16(+) monocytes by exercise.
Birgit Steppich,Farshid Dayyani,Rudolf Gruber,Reinhard Lorenz,Matthias Mack,H. W. Löms Ziegler-Heitbrock +5 more
TL;DR: It is shown that in human peripheral blood the effect of exercise on the number of CD14(+)CD16(+) monocytes as determined by two-color immunofluorescence and flow cytometry shows a dramatic up to 4.8-fold increase in this type of monocyte.
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Steps in prostate cancer progression that lead to bone metastasis
TL;DR: Although many of these processes still need to be fully elucidated, a better understanding of the complex tumor/microenvironment interplay is slowly leading to more effective therapies for patients with prostate cancer bone metastases.