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William G. Bornman
Researcher at University of Texas MD Anderson Cancer Center
Publications - 2
Citations - 269
William G. Bornman is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Stromal cell & Vemurafenib. The author has an hindex of 2, co-authored 2 publications receiving 244 citations.
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Journal ArticleDOI
Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
Muling Mao,Feng Tian,John M. Mariadason,Chun C. Tsao,Robert Lemos,Farshid Dayyani,Y.N. Vashisht Gopal,Zhi-Qin Jiang,Ignacio I. Wistuba,Xi M. Tang,William G. Bornman,Gideon Bollag,Gordon B. Mills,Garth Powis,Jayesh Desai,Gary E. Gallick,Michael A. Davies,Scott Kopetz +17 more
TL;DR: It is shown that activation of the PI3K/AKT pathway is a mechanism of both innate and acquired resistance to BRAF inhibitors in BRAFV600E CRC and suggest combinatorial approaches to improve outcomes in this poor prognosis subset of patients.
Journal ArticleDOI
HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance
David L. Schwartz,James A. Bankson,Luc Bidaut,Yi He,Ryan R. Williams,Robert Lemos,Arun Kumar Thitai,Junghwan Oh,Andrei Volgin,Suren Soghomonyan,Hsin Hsien Yeh,Ryuichi Nishii,Uday Mukhopadhay,Mian M. Alauddin,Ioseb Mushkudiani,Norihito Kuno,Sunil Krishnan,William G. Bornman,Stephen Y. Lai,Garth Powis,John D. Hazle,Juri G. Gelovani +21 more
TL;DR: The results illustrate that tumor radioresistance is mediated by a capacity to compensate for stromal vascular disruption through HIF-1–dependent proangiogenic signaling and that clinically relevant vascular imaging techniques can spatially define mechanisms associated with tumor irradiation.