F
Fatima El-Assaad
Researcher at University of Sydney
Publications - 25
Citations - 887
Fatima El-Assaad is an academic researcher from University of Sydney. The author has contributed to research in topics: Cerebral Malaria & Plasmodium berghei. The author has an hindex of 14, co-authored 22 publications receiving 747 citations. Previous affiliations of Fatima El-Assaad include University of New South Wales & St George's Hospital.
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Journal ArticleDOI
Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis
Mark J. Hackett,James A. McQuillan,Fatima El-Assaad,Jade B. Aitken,Aviva Levina,David D. Cohen,Rainer Siegele,Elizabeth A. Carter,Georges E. Grau,Nicholas H. Hunt,Peter A. Lay +10 more
TL;DR: The results provide strong evidence that amino acids, carbohydrates, lipids, phosphates, proteins and ions, such as Cl(-) and K(+), leach from tissue sections into the aqueous fixative medium during formalin fixation of the sections.
Journal ArticleDOI
Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells.
Dorothée Faille,Fatima El-Assaad,Andrew J. Mitchell,Andrew J. Mitchell,Marie-Christine Alessi,Giovanna Chimini,Thierry Fusai,Georges E. Grau,Valery Combes +8 more
TL;DR: Findings identify new processes by which PMP could modify endothelial cell phenotype and functions, involving mechanisms consistent with both phagocytosis and macropinocytotic.
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Microvesiculation and cell interactions at the brain–endothelial interface in cerebral malaria pathogenesis
Valery Combes,Fatima El-Assaad,Dorothée Faille,Ronan Jambou,Nicholas H. Hunt,Georges E. Grau +5 more
TL;DR: Evidence is presented that intervention studies on MP production, via either gene knockout or pharmacological inhibition, can prevent the neurological syndrome and its associated mortality, suggesting potential new therapeutic avenues.
Journal ArticleDOI
Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis
Saparna Pai,Jim S. Qin,Lois L. Cavanagh,Andrew J. Mitchell,Fatima El-Assaad,Rohit Jain,Valery Combes,Nicholas H. Hunt,Georges E. Grau,Wolfgang Weninger +9 more
TL;DR: These studies define the real-time kinetics of leukocyte behaviour in the central nervous system during ECM, and reveal a significant role for Plasmodium-specific CD8+ T lymphocytes in regulating vascular pathology in this disease.
Journal ArticleDOI
Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.
Dorothée Faille,Fatima El-Assaad,Marie-Christine Alessi,Thierry Fusai,Valery Combes,Georges E. Grau +5 more
TL;DR: Evidence for infection-induced changes in platelets and endothelial cells occur in cerebral malaria, resulting in their concomitant activation, increased interactions between these two cell types, and a secondary pro coagulant or hypercoagulable state.