F
Federica Verdirosa
Researcher at University of Siena
Publications - 10
Citations - 90
Federica Verdirosa is an academic researcher from University of Siena. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 5 publications receiving 23 citations.
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Journal ArticleDOI
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors
Laurent Gavara,Laurent Sevaille,Filomena De Luca,Paola Sandra Mercuri,Carine Bebrone,Georges Feller,Alice Legru,Giulia Cerboni,Silvia Tanfoni,Damien Baud,Giuliano Cutolo,Benoît Bestgen,Giulia Chelini,Federica Verdirosa,Filomena Sannio,Cecilia Pozzi,Manuela Benvenuti,Karolina Kwapien,Marina Fischer,Katja Becker,Jean-Marie Frère,Stefano Mangani,Nohad Gresh,Dorothée Berthomieu,Moreno Galleni,Jean Denis Docquier,Jean-François Hernandez +26 more
TL;DR: A large number of 4-amino-1,2,4-triazole-3-thione-derived Schiff bases were synthesized and characterized, showing that, although moderately potent, they represented a promising basis for the development of broad-spectrum MBL inhibitors.
Journal ArticleDOI
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases.
Francesca Spyrakis,Francesca Spyrakis,Matteo Santucci,Lorenzo Maso,Simon Cross,Eleonora Gianquinto,Filomena Sannio,Federica Verdirosa,Filomena De Luca,Jean Denis Docquier,Laura Cendron,Donatella Tondi,Alberto Venturelli,Gabriele Cruciani,Maria Paola Costi +14 more
TL;DR: The binary complexes of the two most promising compounds binding NDM-1 and VIM-2 were obtained at high resolution, providing strong insights to improve molecular docking simulations, especially regarding the interaction of MBLs with inhibitors.
Journal ArticleDOI
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.
Alice Legru,Federica Verdirosa,Jean-François Hernandez,G. Tassone,Filomena Sannio,Manuela Benvenuti,Pierre-Alexis Conde,Guillaume Bossis,Caitlyn A. Thomas,Michael W. Crowder,Melissa Dillenberger,Katja Becker,Cecilia Pozzi,Stefano Mangani,Jean Denis Docquier,Jean Denis Docquier,Laurent Gavara +16 more
TL;DR: In this paper, the potential of compounds based on the 1,2,4-triazole-3-thione scaffold as an original ligand of the di-zinc active sites of MBLs was explored.
Journal ArticleDOI
4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition.
Laurent Gavara,Federica Verdirosa,Alice Legru,Paola Sandra Mercuri,Lionel Nauton,Laurent Sevaille,Georges Feller,Dorothée Berthomieu,Filomena Sannio,Francesca Marcoccia,Silvia Tanfoni,Filomena De Luca,Nohad Gresh,Moreno Galleni,Jean Denis Docquier,Jean-François Hernandez +15 more
TL;DR: A new series of 1,2,4-triazole-3-thione compounds as inhibitors of metallo-β-lactamases (MBLs), which represent major resistance determinants to β- lactams, and especially carbapenems, in Gram-negative bacteria.
Journal ArticleDOI
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors.
Laurent Gavara,Alice Legru,Federica Verdirosa,Laurent Sevaille,Lionel Nauton,Giuseppina Corsica,Paola Sandra Mercuri,Filomena Sannio,Georges Feller,Rémi Coulon,Filomena De Luca,Giulia Cerboni,Silvia Tanfoni,Giulia Chelini,Moreno Galleni,Jean Denis Docquier,Jean Denis Docquier,Jean-François Hernandez +17 more
TL;DR: In this article, a series of compounds possessing a diversely functionalized alkyl chain at the 4-position of the heterocycle of the 1,2,4-triazole-3-thione scaffold have been characterized.