F
Fei Zhang
Researcher at Fudan University
Publications - 5
Citations - 574
Fei Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Genotype & Hepatitis B virus. The author has an hindex of 5, co-authored 5 publications receiving 504 citations.
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Journal ArticleDOI
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Jianhua Li,Kuancheng Liu,Yang Liu,Yan Xu,Fei Zhang,Huijuan Yang,Jiangxia Liu,Tingting Pan,Jieliang Chen,Min Wu,Xiaohui Zhou,Zhenghong Yuan +11 more
TL;DR: An antiviral mechanism of IFN-α activity that involves the induction and intercellular transfer of antiviral molecules via exosomes is proposed and contributed to the antiviral response of IFn-α to mouse hepatitis virus A59 and adenovirus in mice.
Journal ArticleDOI
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.
TL;DR: It is found that overexpression of viperin could inhibit HCV replication in a dose-dependent manner in both the replicon and HCVcc systems and binding to host protein hVAP-33 and interfering with its interaction with NS5A is suggested.
Journal ArticleDOI
Characterization of contrasting features between hepatitis B virus genotype A and genotype D in small envelope protein expression and surface antigen secretion
Fei Zhang,Xiaoli Tang,Tamako Garcia,Anna S. Lok,Yongxiang Wang,Haodi Jia,Yanli Qin,Chaoyang Chen,Yumei Wen,Jisu Li,Shuping Tong,Shuping Tong +11 more
TL;DR: It is shown that HBV genotypes A and D differ in S protein expression, secretion and modulation by L protein, and that the S protein of genotype D was more efficient at secretion, while its L protein possessed greater inhibitory effect.
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Functional characterization of hepatitis B virus core promoter mutants revealed transcriptional interference among co-terminal viral mRNAs.
Chaoyang Chen,Haodi Jia,Fei Zhang,Yanli Qin,Li Zong,Quan Yuan,Yongxiang Wang,Ningshao Xia,Jisu Li,Yumei Wen,Shuping Tong,Shuping Tong +11 more
TL;DR: Pregenomic RNA of the related duck HBV has been reported to interfere with transcription of the subgenomic RNAs, which might explain why HBV produces so little 0.7 kb RNA and HBx protein despite a strong X promoter.
Journal ArticleDOI
The Envelope Gene of Hepatitis B Virus Is Implicated in Both Differential Virion Secretion and Genome Replication Capacities between Genotype B and Genotype C Isolates
Haodi Jia,Yanli Qin,Chaoyang Chen,Fei Zhang,Cheng Li,Li Zong,Yongxiang Wang,Jiming Zhang,Jisu Li,Yumei Wen,Shuping Tong,Shuping Tong +11 more
TL;DR: Surprisingly, exchanging the entire envelope gene or just its S region could enhance virion secretion by genotype B clones while diminishing virions secretion by Genotype C clones, although the underlying mechanism remains to be clarified.