F
Feifei Feng
Researcher at Shandong University
Publications - 12
Citations - 153
Feifei Feng is an academic researcher from Shandong University. The author has contributed to research in topics: Medicine & SMAD. The author has an hindex of 5, co-authored 7 publications receiving 60 citations.
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Journal ArticleDOI
Tanshinone IIA attenuates silica-induced pulmonary fibrosis via inhibition of TGF-β1-Smad signaling pathway.
TL;DR: Tan IIA is determined to ameliorate silicosis fibrosis partially by suppressing activation of TGF-β1-Smad signaling pathway, which may turn out to be a potential therapeutic approach to prevent silicotic fibrosis.
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Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-β1/Smad signaling.
TL;DR: It is found that in vivo treatment with Tan IIA significantly relieved silica-induced lung fibrosis in a silicosis rat model by histological and immunohistochemical analyses and in vitro mechanistic investigations revealed that Nrf2 activation partially mediates the suppression effects ofTan IIA on EMT and TGF-β1/Smad signaling pathway activation induced by silica exposure.
Journal ArticleDOI
The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation.
TL;DR: It is suggested that Tan IIA may protect lung from silica damage via the suppression of TGF-β1/Smad signaling, inhibition of NOX4 expression and activation of the Nrf2/ARE pathway.
Journal ArticleDOI
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition.
TL;DR: Investigation of the mechanism revealed that the PPI and PPVII significantly upregulated the p53, induced caspase-dependent apoptosis and suppressed the CIP2A/AKT/mTOR pathway, and it is proposed that P PI and PP VII might be developed as candidate drugs for DDP-resistant NSCLC.
Journal ArticleDOI
Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis.
TL;DR: Results from the present study demonstrated that PPI and PPVII may function as chemosensitizers by enhancing apoptosis via the p53 pathway, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis, and the combination with DDP may be a promising strategy for the development of new therapeutic agents.