Showing papers in "Biomedicine & Pharmacotherapy in 2020"

TL;DR: The mechanism of regulating pyroptosis in tumor cells as well as the potential roles of pyroPTosis in cancer are focused on to explore potential diagnostic markers in cancers contributing to the prevention and treatment in cancers.

TL;DR: A better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroPTosis inhibitors to address inflammation.

TL;DR: The evidence for the pharmacological potential and inhibition of quercetin on cancers, supporting the viewpoint that quercETin should be adequately considered as a therapeutic agent against various cancers is summarized.

TL;DR: An overview of recent developments in immunotherapy is given and a new direction of tumor treatment is indicated through analyzing the pros and cons of immunotherapy coupled with keeping a close watch on the development trend of the immunotherapy future.

TL;DR: This paper will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of Sars-Cov-2 infection.

TL;DR: In this paper, the expression pattern and signal transduction pathways of IL-1β and TNF-α are reviewed, and their similar and different roles in IDD are focused on.

TL;DR: Plant polyphenols possess potent antioxidant and anti-inflammatory properties and can inhibit ROS production and inflammation in chondrocytes, cartilage explants and in animal models of OA.

TL;DR: It seems that there is a potential involvement of ACE2 and TMPRSS2 expressions in the virus infection of extrapulmonary organs and the manifestation of symptoms related to these organs in patients with COVID-19.

TL;DR: Given the current emergency caused by the COVID-19 pandemic and limited therapeutic options, propolis is presented as a promising and relevant therapeutic option that is safe, easy to administrate orally and is readily available as a natural supplement and functional food.

TL;DR: The experimental studies on SIT gives a clear evidence that the potential phytosterol can be used as supplements to fight against life threatening diseases.

TL;DR: Given the pathological complexity of the said disease, nanotechnology-based approaches are more enticing as it comes with added advantage of site-specific drug delivery with higher bioavailability and reduced dosage regimen.

TL;DR: The manuscript reviewed the pharmacological effects of isorhamnetin and related mechanisms of action for the development of its medicinal properties further and highlighted the need for detailed scientific validation on its mechanism of action.

TL;DR: Fisetin alleviated kidney inflammation and apoptosis to protect against LPS-induced septic AKI mice via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways.

TL;DR: Taken together, H19 is regarded as a biomarker for cancer and a putative therapeutic target in these human disorders.

TL;DR: The research of obesity drug treatment with PL inhibitors is discussed and a brief review of related properties and the use of PL inhibitors in the field of weight loss is offered.

TL;DR: The role of lncRNA-miRNA-mRNA axis in the development of OS is highlighted to provide novel approaches for cancer diagnosis and treatment.

TL;DR: The most relevant molecular mechanisms of action and regulation of WNT/β-catenin signaling in the development and pathophysiology of liver cancers, as well as in the developed of therapeutics are discussed.

TL;DR: An updated overview of the natural history and current knowledge on drugs and therapeutic agents being tested for the prevention and treatment of COVID-19 and potential drugs used to prevent, control and treat patients worldwide are provided.

TL;DR: Researchers have published reports of specific monoclonal antibodies against to COVID-19 (B38, H4, 47D11) and hope that this method is effective and demonstrates the potential of monOClonal antibody therapy as a therapeutic approach and prevention of covid-19 infection.

TL;DR: The underlying mechanism of GA and FY capsule against gastric ulcer in rats caused by ethanol might be involved in Nrf2/HO-1 anti-oxidative pathway and ultimately played an anti-apoptotic role through regulating Bax, Bcl-2 and Caspase-3.

TL;DR: Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation and two main therapeutic strategies that target the TGF-β/Smad pathway to attenuate abnormal skin scar formation are evaluated.

TL;DR: The evidence of the Nrf2 modulating hypothesis as a possible molecular mechanism underlying the medicinal properties of resveratrol is reviewed.

TL;DR: The drug delivery applications of NCDs particularly as sensing and real-time tracing probe, antimicrobial, anticancer, neurodegenerative agents are reviewed as an initiative to strengthen the case of N CDs as potent drug delivery agents.

TL;DR: It is suggested that puerarin has anti-inflammatory and anti-oxidative effects in the mouse model of colitis and significantly inhibited inflammation through the down-regulation of nuclear factor-κB and the secretion of pro-inflammatory mediators.

TL;DR: This review provides a general perspective of the immune system, the gut immune system and its microbiota, and evaluates functional foods with critical but comprehensive perspectives into probiotics and prebiotics, their immune boosting and mechanisms of action.

TL;DR: This review will summarize research progress of antitumor TCM that regulates the immune system, including both innate immunity, such as macrophages, dendritic cells, natural killer cells and MDSCs, and adaptive immunity, including CD4+/CD8+ T lymphocytes, regulatory T cells (Tregs) and B cells.

TL;DR: Salivary exosomal miR-24-3p is a potential novel diagnostic biomarker for OSCC, and miR+3p can maintain the proliferation of OSCC cells through targeting PER1, and dual luciferase reporter assay indicated that miR&D can interact with PER1 directly.

TL;DR: The anti-diabetic effect of 14 probiotics in db/db mice seem to be related to an increase of SCFA-producing bacteria, the improvement of intestinal barrier function and the upregulation of GLP-1 production, and indicate these probiotics might be a good candidate to prevent and treat diabetes.

TL;DR: It is of great significance to understand how to select appropriate exosomes loaded with biomolecules or chemical drugs for different tumors types, and how to deliver exosome to recipient cells accurately and efficiently.

TL;DR: The findings suggest that LBP is a good source as a potential prebiotic and can enhance the intestinal microbiota and boost beneficial bacteria levels, modulate innate immune response.