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Felix Scheuplein
Researcher at University of Hamburg
Publications - 26
Citations - 1701
Felix Scheuplein is an academic researcher from University of Hamburg. The author has contributed to research in topics: T cell & NOD mice. The author has an hindex of 15, co-authored 26 publications receiving 1572 citations.
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Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Janusz Wesolowski,Vanina Alzogaray,Jan Reyelt,Mandy Unger,Karla Juarez,Karla Juarez,Mariela Urrutia,Ana Cauerhff,Welbeck Danquah,Björn Rissiek,Felix Scheuplein,Nicole Schwarz,Sahil Adriouch,Olivier Boyer,Michel Seman,Alexei Licea,David V. Serreze,Fernando Alberto Goldbaum,Friedrich Haag,Friedrich Koch-Nolte +19 more
TL;DR: The results of several recent proof-of-principle studies are reviewed that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
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NAD-Induced T Cell Death: ADP-Ribosylation of Cell Surface Proteins by ART2 Activates the Cytolytic P2X7 Purinoceptor
Michel Seman,Sahil Adriouch,Felix Scheuplein,Christian Krebs,Dunja Freese,Gustavo Glowacki,Phillipe Deterre,Friedrich Haag,Friedrich Koch-Nolte +8 more
TL;DR: These results delineate an alternative mechanism for inducing T cell death and set an interesting precedent for immunoregulation via crosstalk between NAD-dependent ADP-ribosyltransferases and purinoceptors.
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Extracellular NAD and ATP: Partners in immune cell modulation.
Friedrich Haag,Sahil Adriouch,Anette Braß,Caroline Jung,Sina Möller,Felix Scheuplein,Peter Bannas,Michel Seman,Friedrich Koch-Nolte +8 more
TL;DR: P2X7-mediated NAD-induced cell death (NICD) specifically targets this cell population and may inhibit bystander activation of unprimed T cells, reducing the risk of autoimmunity and augment an immune response.
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Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo
Friedrich Koch-Nolte,Jan Reyelt,Britta Schößow,Nicole Schwarz,Felix Scheuplein,Stefan Rothenburg,Friedrich Haag,Vanina Alzogaray,Ana Cauerhff,Fernando Alberto Goldbaum +9 more
TL;DR: A proof of principle that opens up a new avenue for targeting leukocyte ecto‐enzymes in vivo and that can serve as a model also for developing new antidotes against ADP‐ribosylating toxins is formed.
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NAD+ and ATP Released from Injured Cells Induce P2X7-Dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells
Felix Scheuplein,Nicole Schwarz,Sahil Adriouch,Christian Krebs,Peter Bannas,Björn Rissiek,Michel Seman,Friedrich Haag,Friedrich Koch-Nolte +8 more
TL;DR: It is shown that lysis of erythrocytes releases sufficient levels of NAD+ and ATP to induce activation of P2X7, and that signaling by ATP fades more rapidly than that by NAD+.