F
Feng Wan
Researcher at Heidelberg University
Publications - 6
Citations - 454
Feng Wan is an academic researcher from Heidelberg University. The author has contributed to research in topics: Glioma & Retinoic acid. The author has an hindex of 4, co-authored 4 publications receiving 406 citations. Previous affiliations of Feng Wan include Huazhong University of Science and Technology.
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Journal ArticleDOI
Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
Benito Campos,Feng Wan,Feng Wan,Mohammad Farhadi,Aurélie Ernst,Felix Zeppernick,Katrin E. Tagscherer,Rezvan Ahmadi,Jennifer Lohr,Christine Dictus,Georg Gdynia,Stephanie E. Combs,Violaine Goidts,Burkhard Helmke,Volker Eckstein,Wilfried Roth,Philipp Beckhove,Peter Lichter,Andreas Unterberg,Bernhard Radlwimmer,Christel Herold-Mende +20 more
TL;DR: It is shown that all-trans retinoic acid treatment alone can induce antitumor effects in vivo, and the potential of differentiation treatment to target the stem-like cell population in glioblastoma is highlighted.
Journal ArticleDOI
Aberrant Expression of Retinoic Acid Signaling Molecules Influences Patient Survival in Astrocytic Gliomas
Benito Campos,Franz-Simon Centner,Justo Lorenzo Bermejo,Justo Lorenzo Bermejo,Ramadan Ali,Katharina Dorsch,Feng Wan,Feng Wan,Jörg Felsberg,Rezvan Ahmadi,Niels Grabe,Guido Reifenberger,Andreas Unterberg,Jürgen Burhenne,Christel Herold-Mende +14 more
TL;DR: The data indicate a complex and clinically relevant deregulation of RA signaling, which seems to be a central event in glioma pathogenesis, influencing patient prognosis.
Journal ArticleDOI
Association of Stem Cell-Related Markers and Survival in Astrocytic Gliomas
Feng Wan,Christel Herold-Mende,Benito Campos,Franz Simon Centner,Christine Dictus,Natalia Becker,Frauke Devens,Carolin Mogler,Jörg Felsberg,Niels Grabe,Guido Reifenberger,Peter Lichter,Andreas Unterberg,Justo Lorenzo Bermejo,Justo Lorenzo Bermejo,Rezvan Ahmadi +15 more
TL;DR: The findings suggest that immature glioma cells are involved in tumour growth and tumour progression and significantly impact on patient prognosis.
Journal ArticleDOI
Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas
Rebecca Schüle,Christine Dictus,Benito Campos,Feng Wan,Jörg Felsberg,Rezvan Ahmadi,Franz-Simon Centner,Niels Grabe,Guido Reifenberger,Justo Lorenzo Bermejo,Andreas Unterberg,Christel Herold-Mende +11 more
TL;DR: It is demonstrated that β-catenin expression in astrocytomas is associated with increased malignancy and adverse outcome and canonical wnt pathway activation in high-grade gliomas is reported on.
Journal ArticleDOI
TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling
Peng Peng,Hongtao Zhu,Dan Liu,Zirong Chen,Xiaoling Zhang,Zhongyi Guo,Minhai Dong,Lijun Wan,Po Zhang,Guohai Liu,Suojun Zhang,Fangyong Dong,Feng Hu,Fangling Cheng,Shijun Huang,Dongsheng Guo,Bin Zhang,Xingjiang Wu,Feng Wan +18 more
TL;DR: TGFBI promoted the maintenance of GSCs and GBM malignant growth through integrin αvβ5-Src-Stat3 signaling in vitro and in vivo and may serve as a potential diagnostic and prognostic bio-index for GBMs.