Fengqin Wang

TL;DR: A characterization of the full m6A methyltransferase complex in HeLa cells is reported identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and it is shown that VIRMA mediates preferential mRNA methylation in 3′UTR and near stop codon.

TL;DR: The functional importance of the m6A methylation machinery in autophagy and adipogenesis regulation is unveiled, which expands the understanding of such interplay that is essential for development of therapeutic strategies in the prevention and treatment of obesity.

TL;DR: The authors developed a metabolic labeling method via incorporation of allyl-SAM analogs to profile transcriptome-wide m6A at base resolution, which enables identification of m 6A motifs and clustered m5-methyladenosine sites and holds promise to locate nuclear nascent RNA m6a modifications.

TL;DR: BNS particles were found to protect the mouse intestinal barrier function and preserve intestinal redox homeostasis more efficiently than SeMet and Nano-Se, suggesting that BNS is a promising selenium species with potential application in treating oxidative stress-related intestinal diseases.

TL;DR: It is demonstrated that silencing FTO inhibited adipogenesis of preadipocytes through impairing cell cycle progression at the early stage of adipogenesis, which provides insights into critical roles of m6A methylation in adipogenesis.