G
Guan-Zheng Luo
Researcher at Sun Yat-sen University
Publications - 71
Citations - 7025
Guan-Zheng Luo is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 30, co-authored 68 publications receiving 4486 citations. Previous affiliations of Guan-Zheng Luo include University of Chicago & Chinese Academy of Sciences.
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Journal ArticleDOI
YTHDC1 mediates nuclear export of N 6 -methyladenosine methylated mRNAs.
Ian A Roundtree,Guan-Zheng Luo,Guan-Zheng Luo,Zijie Zhang,Zijie Zhang,Xiao Wang,Xiao Wang,Tao Zhou,Yiquang Cui,Jiahao Sha,Xingxu Huang,Laura Guerrero,Laura Guerrero,Phil Xie,Phil Xie,Emily He,Emily He,Bin Shen,Chuan He,Chuan He +19 more
TL;DR: It is shown that the m6A-binding protein YTHDC1 mediates export of methylated mRNA from the nucleus to the cytoplasm in HeLa cells, and supports an emerging paradigm of m 6A as a distinct biochemical entity for selective processing and metabolism of mammalian mRNAs.
Journal ArticleDOI
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
Phillip J. Hsu,Yunfei Zhu,Honghui Ma,Honghui Ma,Yueshuai Guo,Xiaodan Shi,Yuanyuan Liu,Meijie Qi,Zhike Lu,Zhike Lu,Hailing Shi,Hailing Shi,Jianying Wang,Yiwei Cheng,Guan-Zheng Luo,Guan-Zheng Luo,Qing Dai,Qing Dai,Mingxi Liu,Xuejiang Guo,Jiahao Sha,Bin Shen,Chuan He,Chuan He +23 more
TL;DR: YTHDC2 is an m6A-binding protein that plays critical roles during spermatogenesis and enhances the translation efficiency of its targets and also decreases their mRNA abundance.
Journal ArticleDOI
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
Yanan Yue,Jun Liu,Xiaolong Cui,Jie Cao,Guan-Zheng Luo,Zezhou Zhang,Tao Cheng,Minsong Gao,Xiao Shu,Honghui Ma,Fengqin Wang,Xinxia Wang,Bin Shen,Yizhen Wang,Xinhua Feng,Chuan He,Jianzhao Liu,Jianzhao Liu +17 more
TL;DR: A characterization of the full m6A methyltransferase complex in HeLa cells is reported identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and it is shown that VIRMA mediates preferential mRNA methylation in 3′UTR and near stop codon.
Journal ArticleDOI
N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas
Ye Fu,Guan-Zheng Luo,Guan-Zheng Luo,Kai Chen,Kai Chen,Xin Deng,Xin Deng,Miao Yu,Miao Yu,Dali Han,Dali Han,Ziyang Hao,Ziyang Hao,Jianzhao Liu,Jianzhao Liu,Xingyu Lu,Xingyu Lu,Louis C. Dore,Louis C. Dore,Xiaocheng Weng,Xiaocheng Weng,Quanjiang Ji,Quanjiang Ji,Laurens Mets,Chuan He,Chuan He +25 more
TL;DR: A comprehensive analysis of the 6mA landscape in the genome of Chlamydomonas using new sequencing approaches finds that 6mA mainly locates at ApT dinucleotides around transcription start sites (TSS) with a bimodal distribution and appears to mark active genes.
Journal ArticleDOI
RNA m 6 A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail.
Xinyao Lin,Guo-Shi Chai,Yingmin Wu,Jiexin Li,Feng Chen,Jianzhao Liu,Guan-Zheng Luo,Guan-Zheng Luo,Jordi Tauler,Jun Du,Shuibin Lin,Chuan He,Hong-Sheng Wang +12 more
TL;DR: It is shown that m6A methylation of Snail mRNA regulates its translation with potential effects on epithelial mesenchymal transition, and the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival rate of liver cancer patients.