F
Fengxiao Bu
Researcher at University of Iowa
Publications - 19
Citations - 890
Fengxiao Bu is an academic researcher from University of Iowa. The author has contributed to research in topics: Atypical hemolytic uremic syndrome & Thrombotic microangiopathy. The author has an hindex of 11, co-authored 15 publications receiving 757 citations. Previous affiliations of Fengxiao Bu include Roy J. and Lucille A. Carver College of Medicine & University of Iowa Hospitals and Clinics.
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Journal ArticleDOI
Comprehensive Genetic Analysis of Complement and Coagulation Genes in Atypical Hemolytic Uremic Syndrome
Fengxiao Bu,Tara Maga,Nicole C. Meyer,Kai Wang,Christie P. Thomas,Carla M. Nester,Richard J.H. Smith +6 more
TL;DR: Mutation screening in patients with aHUS should be broadened to include genes in the coagulation pathway, as there are strong lines of evidence supporting the presence of additional genetic contributions to this disease.
Journal ArticleDOI
Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects
Fengxiao Bu,Laura A.G. Armas,Joan M. Lappe,Yu Zhou,Guimin Gao,Hong Wei Wang,Robert R. Recker,Lan Juan Zhao +7 more
TL;DR: Nine important genes in vitamin D metabolic pathways are screened using 49 single nucleotide polymorphism (SNP) markers and results suggest that the CYP2R1 and GC genes may contribute to the variation of serum 25(OH)D levels in healthy populations.
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Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.
Amy J. Osborne,Matteo Breno,Nicolò Borsa,Fengxiao Bu,Fengxiao Bu,Véronique Frémeaux-Bacchi,Daniel P. Gale,Lambertus P. van den Heuvel,Lambertus P. van den Heuvel,David J. Kavanagh,Marina Noris,Sheila Pinto,Pavithra M. Rallapalli,Giuseppe Remuzzi,Giuseppe Remuzzi,Santiago Rodríguez de Córdoba,Angela Ruiz,Richard J.H. Smith,Paula Vieira-Martins,Elena B. Volokhina,Valerie Wilson,Timothy H.J. Goodship,Stephen J. Perkins +22 more
TL;DR: The RV analyses showed nonrandom distributions over the affected proteins, and different distributions were observed between aHUS and C3G that clarify their phenotypes.
Journal ArticleDOI
High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies
Fengxiao Bu,Nicolò Borsa,Michael N. Jones,Erika Takanami,Carla Nishimura,Jill Hauer,Hela Azaiez,Elizabeth A. Black-Ziegelbein,Nicole C. Meyer,Diana L. Kolbe,Yingyue Li,Kathy L. Frees,Michael J. Schnieders,Christie P. Thomas,Carla M. Nester,Richard J.H. Smith +15 more
TL;DR: A comprehensive genetic panel that screens all exons of all genes implicated in TMA and C3Gs was able to provide a positive genetic diagnosis in 43% and 41% of patients carrying the clinical diagnosis of C3G and TMA, respectively.
Journal ArticleDOI
TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss.
Hela Azaiez,Kevin T. Booth,Fengxiao Bu,Patrick L. M. Huygen,S.B. Shibata,Aiden Eliot Shearer,Aiden Eliot Shearer,Diana L. Kolbe,Nicole C. Meyer,E.A. Black-Ziegelbein,Richard J.H. Smith,Richard J.H. Smith +11 more
TL;DR: A unique variant, p.Ser178Leu, in TBC1D24 that segregates with the hearing loss phenotype is identified and its change is predicted to be damaging.