P
Paula Vieira-Martins
Researcher at French Institute of Health and Medical Research
Publications - 12
Citations - 584
Paula Vieira-Martins is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Complement system & Atypical hemolytic uremic syndrome. The author has an hindex of 9, co-authored 11 publications receiving 412 citations.
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Journal ArticleDOI
Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.
Régis Peffault de Latour,Véronique Frémeaux-Bacchi,Raphaël Porcher,Aliénor Xhaard,Jérémie Rosain,Diana Cadena Castaneda,Paula Vieira-Martins,Stéphane Roncelin,Paula Rodriguez-Otero,Aurélie Plessier,Flore Sicre de Fontbrune,Sarah Abbes,Marie Robin,Gérard Socié,Gérard Socié +14 more
TL;DR: It is suggested that both CH50 activity and circulating free eculizumab levels may help physicians to manage PNH patients receiving eculIZumab.
Journal ArticleDOI
Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.
Amy J. Osborne,Matteo Breno,Nicolò Borsa,Fengxiao Bu,Fengxiao Bu,Véronique Frémeaux-Bacchi,Daniel P. Gale,Lambertus P. van den Heuvel,Lambertus P. van den Heuvel,David J. Kavanagh,Marina Noris,Sheila Pinto,Pavithra M. Rallapalli,Giuseppe Remuzzi,Giuseppe Remuzzi,Santiago Rodríguez de Córdoba,Angela Ruiz,Richard J.H. Smith,Paula Vieira-Martins,Elena B. Volokhina,Valerie Wilson,Timothy H.J. Goodship,Stephen J. Perkins +22 more
TL;DR: The RV analyses showed nonrandom distributions over the affected proteins, and different distributions were observed between aHUS and C3G that clarify their phenotypes.
Journal ArticleDOI
Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome
Elizabeth C. Schramm,Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina,Tania Rybkine,Tania Rybkine,Tania Rybkine,Sophie Chauvet,Sophie Chauvet,Sophie Chauvet,Paula Vieira-Martins,Christophe Hue,Christophe Hue,Christophe Hue,Tara Maga,Elisabetta Valoti,Valerie Wilson,T. Sakari Jokiranta,Richard J.H. Smith,Marina Noris,Timothy H.J. Goodship,John P. Atkinson,Véronique Frémeaux-Bacchi +22 more
TL;DR: This study expands the knowledge of the functional consequences of aHUS-associated C3 mutations relative to the interaction of C3 with complement regulatory proteins mediating cofactor activity.
Journal ArticleDOI
Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors
Alice Le Clech,Noémie Simon-Tillaux,François Provôt,Yahsou Delmas,Paula Vieira-Martins,Sophie Limou,Sophie Limou,Jean-Michel Halimi,Moglie Le Quintrec,Ludivine Lebourg,Steven Grangé,Alexandre Karras,David Ribes,Noémie Jourde-Chiche,Eric Rondeau,Véronique Frémeaux-Bacchi,Fadi Fakhouri +16 more
TL;DR: Patients treated with eculizumab presented with more severe HUS and were more likely to require dialysis at the time of diagnosis as compared to patients not treated, and rates of hematological remission, chronic kidney disease, and end-stage renal disease were similar in the two groups.
Journal ArticleDOI
Defining the genetics of thrombotic microangiopathies.
Paula Vieira-Martins,Carine El Sissy,Pauline Bordereau,Aurelia Gruber,Jérémie Rosain,Véronique Frémeaux-Bacchi +5 more
TL;DR: In this review, genetic mutations characteristic of certain TMAs are described and their contributions to disease are reviewed and several more genes have been implicated.