Showing papers by "Fernando Fernández-Bañares published in 2018"
TL;DR: Oral budesonide 9 mg once daily was found to be effective and safe for induction of clinical and histologic remission in patients with lymphocytic colitis, compared with placebo.
43 citations
TL;DR: Standard direct cost of the majority of AEP is reported using a methodology that enables easy application in other centers, and for the most part, endoscopic procedures are more cost-efficient than the corresponding surgical procedure.
12 citations
TL;DR: A negative POCT allows ruling out CD in primary care, making it suitable for case-finding, and POCT followed by duodenal biopsy was the most cost-effective approach.
Abstract: BackgroundAn on-site, rapid, fingertip, whole-blood point-of-care test (POCT) is attractive for active case-finding of coeliac disease (CD) in primary care because of its simplicity.AimThe aim of this article is to assess the usefulness and cost-effectiveness of adult case-finding using a POCT based on deamidated gliadin peptide antibodies (IgA/IgG-DGP) in primary care for CD diagnosis.MethodsA case-finding study for CD was conducted by using an easy-to-use, on-site, whole-blood for IgA/IgG-DGP-based fingertip POCT compared with tTG2 in 350 individuals. Sample size was calculated based on 0.28% prevalence in the reference population. Duodenal biopsies for histology, intraepithelial lymphocytes and in situ deposition of tTG2 were obtained if tTG2 and/or POCT were positive. Accuracy and cost-effectiveness of strategies using serology or POCT were calculated.ResultsPrevalence of CD was 1.14% (95% CI, 0.3–3.4), almost double what was previously observed. Four patients were diagnosed with CD. tTG2 was positive...
10 citations
TL;DR: Aspirin does not modify the diagnostic accuracy of the faecal immunochemical test for CRC and/or AN in patients with gastrointestinal symptoms and the sensitivity, specificity and AUC for AN for these patients were significantly lower than for the non-user group.
Abstract: BackgroundAspirin (ASA) is a drug that can cause gastrointestinal lesions and symptoms. Colorectal cancer (CRC) is the most prevalent type of cancer in Western countries. We assessed the effect of aspirin on the diagnostic accuracy of the faecal immunochemical test (FIT) for CRC and/or advanced neoplasia (AN) in patients undergoing colonoscopy for gastrointestinal symptoms.MethodsWe conducted a prospective multicentre observational study of diagnostic tests that included patients with gastrointestinal symptoms undergoing colonoscopy between March 2012 and 2014 (the COLONPREDICT study). Symptoms were assessed and a FIT and blood tests assessing haemoglobin and carcinoembryonic antigen (CEA) levels were performed.ResultsThe study included 3052 patients: A total of 2567 did not take aspirin (non-user group) and 485 (16%) took aspirin (user group). Continuous treatment with ASA did not change the AUC (0.88, 0.82; p = 0.06), sensitivity (92%, 88%; p = 0.5) or specificity (71%, 67%; p = 0.2) of the FIT for CRC ...
6 citations