Fernando Macedo

TL;DR: In this paper, a review of the most potent antiurease organic substances is presented, focusing on systematic screening studies on the inhibitory activity of rationally designed series of compounds with the corresponding SAR considerations.

TL;DR: An optimized methodology for extraction of β- d -glucan from S. cerevisiae cells, involving sonication and enzyme treatment, with a yield of 11.08 ± 0.19%, is developed and in vitro tests with CM-G did not reveal any cytotoxic or genotoxic effects or influences of this molecule on cell viability.

TL;DR: Out of 28 compounds that effectively inhibited soil ureases activity, BTUs 3, 6, 10, 12, 16, 19 and 22 were determined to be more potent than the reference inhibitor N-(butyl) thiophosphoric triamide (NBPT; 40%).

TL;DR: Sophorolipid demonstrated antimicrobial activity against the tested bacteria and the combined treatment of sophorolipsid and lactic acid represented an additive interaction, suggesting this combination could be an alternative to use as a new natural sanitizer in the poultry industry, reducing the microbial contamination of these main pathogens.

TL;DR: Docking results suggest that thiohydantoin ring could be a pharmacophoric group due to its binding affinity by hydrogens bond interactions with important amino acid residues at the active site of both enzymes.