F
Fiona Doetsch
Researcher at University of Basel
Publications - 49
Citations - 19157
Fiona Doetsch is an academic researcher from University of Basel. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 34, co-authored 47 publications receiving 17983 citations. Previous affiliations of Fiona Doetsch include Rockefeller University & Columbia University.
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Journal ArticleDOI
Stem cells in the nervous system.
Angel R. Maldonado-Soto,Derek H. Oakley,Hynek Wichterle,Joel Stein,Fiona Doetsch,Christopher E. Henderson +5 more
TL;DR: This review focuses on the current understanding of the applications of stem cells in treating ailments of the human brain, with an emphasis on neurodegenerative diseases.
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EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.
TL;DR: An important, locus-specific role for chromatin remodeling in EGFR expression in human neural development that may be dysregulated during gliomagenesis is pointed to, unraveling potential novel targets for future drug therapy.
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Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties
Jessica Tome-Garcia,Rut Tejero,German Nudelman,Raymund Yong,Robert Sebra,Huaien Wang,Mary Fowkes,Margret S. Magid,Martin J. Walsh,Violeta Silva-Vargas,Violeta Silva-Vargas,Elena Zaslavsky,Roland H. Friedel,Fiona Doetsch,Fiona Doetsch,Nadejda M. Tsankova +15 more
TL;DR: A purification strategy to directly isolate EGFR+/− populations from human germinal matrix and adult subventricular zone autopsy tissues, and from de novo glioblastoma resections, enriching for cells capable of binding EGF ligand (LBEGFR+), and uniquely compared their functional and molecular properties.
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A New Twist for Neurotrophins: Endothelial-Derived NT-3 Mediates Adult Neural Stem Cell Quiescence
TL;DR: This issue of Neuron reveals that endothelial-derived NT-3 acts as a mediator of quiescence in the V-SVZ adult neural stem cell niche.
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Symmetric Stem Cell Division at the Heart of Adult Neurogenesis
TL;DR: The primary mode of division of adult ventricular-subventricular zone (V-SVZ) neural stem cells is symmetric, with the majority generating two non-stem cell progeny, and a minority self-renewing.