F
Fioranna Renda
Researcher at New York State Department of Health
Publications - 24
Citations - 620
Fioranna Renda is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Kinetochore & Mitosis. The author has an hindex of 8, co-authored 20 publications receiving 407 citations. Previous affiliations of Fioranna Renda include Sapienza University of Rome.
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Journal ArticleDOI
Nuclear envelope assembly defects link mitotic errors to chromothripsis
Shiwei Liu,Mijung Kwon,Mark Mannino,Mark Mannino,Nachen Yang,Fioranna Renda,Alexey Khodjakov,David Pellman,David Pellman +8 more
TL;DR: It is shown that spindle microtubules block assembly of NPCs and other non-core nuclear envelope proteins on lagging chromosomes, causing an irreversible defect in nuclear envelope assembly, which leads to spontaneous envelope disruption of micronuclei and subsequent genome instability.
Journal ArticleDOI
DNA copy number evolution in Drosophila cell lines
Hangnoh Lee,C. Joel McManus,C. Joel McManus,Dong-Yeon Cho,Matthew L. Eaton,Fioranna Renda,Maria Patrizia Somma,Lucy Cherbas,Gemma E. May,Gemma E. May,Sara K. Powell,Dayu Zhang,Lijun Zhan,Alissa M. Resch,Justen Andrews,Susan E. Celniker,Peter Cherbas,Teresa M. Przytycka,Maurizio Gatti,Brian Oliver,Brenton R. Graveley,David M. MacAlpine +21 more
TL;DR: This study illustrates how genome structure changes may contribute to selection of cell lines in vitro and has implications for other cell-level natural selection progressions, including tumorigenesis.
Journal ArticleDOI
Chromosome Segregation Is Biased by Kinetochore Size.
Danica Drpic,Ana C Almeida,Paulo Aguiar,Fioranna Renda,Joana Damas,Harris A. Lewin,Denis M. Larkin,Alexey Khodjakov,Helder Maiato,Helder Maiato +9 more
TL;DR: Surprisingly, it is found that chromosome segregation in this species is not random and kinetochore size is an important determinant of chromosome segregation fidelity.
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Microtubules assemble near most kinetochores during early prometaphase in human cells
Vitali Sikirzhytski,Fioranna Renda,Irina Tikhonenko,Valentin Magidson,Bruce F. McEwen,Alexey Khodjakov,Alexey Khodjakov +6 more
TL;DR: It is reported that most kinetochores in human cells develop K-fibers via the second mechanism, and conversion from lateral to end-on interactions is impeded upon inhibition of the plus end–directed kinetchore-associated kinesin CenpE.
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A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity.
Chiara Merigliano,Antonio Marzio,Fioranna Renda,Maria Patrizia Somma,Maurizio Gatti,Fiammetta Vernì +5 more
TL;DR: The hypothesis that an improperly phosphorylated Ku70 protein can lead to DNA damage and CABs is suggested, which is consistent with many types of cancer and acts as a tumor suppressor.