F
Florence A. Aeschlimann
Researcher at University of Toronto
Publications - 21
Citations - 336
Florence A. Aeschlimann is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 14 publications receiving 203 citations.
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Journal ArticleDOI
A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease
Florence A. Aeschlimann,Ezgi Deniz Batu,Scott W. Canna,Ellen Go,Ahmet Gül,Patrycja Hoffmann,Helen L. Leavis,Seza Ozen,Daniella M. Schwartz,Deborah L. Stone,Annet Van Royen-Kerkof,Daniel L. Kastner,Ivona Aksentijevich,Ronald M. Laxer +13 more
TL;DR: Early-onset recurrent oral, genital and/or gastrointestinal ulcers are the hallmark feature of HA20, and treatment regimens should be based on disease severity, and cytokine inhibitors are often required to control relapses.
Journal ArticleDOI
Childhood Takayasu arteritis: disease course and response to therapy.
Florence A. Aeschlimann,Simon W. M. Eng,S. Sheikh,Ronald M. Laxer,Diane Hebert,Damien Noone,Marinka Twilt,Christian Pagnoux,Susanne M. Benseler,Rae S. M. Yeung +9 more
TL;DR: Childhood TAK carries a high disease burden; half of the children experienced flares and 7% died; biologic therapies were associated with better control of disease activity.
Journal ArticleDOI
Patterns of joint involvement in juvenile idiopathic arthritis and prediction of disease course: A prospective study with multilayer non-negative matrix factorization.
Simon W. M. Eng,Florence A. Aeschlimann,Mira van Veenendaal,Roberta A. Berard,Roberta A. Berard,Roberta A. Berard,Alan M. Rosenberg,Quaid Morris,Rae S. M. Yeung +8 more
TL;DR: This hierarchical unsupervised approach identified a new clinical feature, degree of localization, which predicted outcomes in both cohorts, which supported both the continued collection of detailed joint involvement and the inclusion of patterns and degrees of localization to stratify patients and inform treatment decisions.
Journal ArticleDOI
Presentation and Disease Course of Childhood-Onset Versus Adult-Onset Takayasu Arteritis.
Florence A. Aeschlimann,Lillian Barra,Roaa Alsolaimani,Susanne M. Benseler,Diane Hebert,Nader Khalidi,Ronald M. Laxer,Damien Noone,Christian Pagnoux,Marinka Twilt,Rae S. M. Yeung +10 more
TL;DR: To compare the clinical features, efficacy and safety of treatment regimens, and outcomes of childhood‐ and adult‐onset Takayasu arteritis (TAK), a large number of patients with both childhood and adult TAKs are surveyed.
Journal ArticleDOI
Risk of Serious Infections Associated with Biologic Agents in Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analyses
Florence A. Aeschlimann,Shu-Ling Chong,Todd W. Lyons,Beate C. Beinvogl,Lina Góez-Mogollón,Sally Tan,Ronald M. Laxer +6 more
TL;DR: In this systematic review and meta‐analyses, serious infections were uncommon and not significantly increased among patients with JIA receiving biologic agents compared with controls, however, the analyses were underpowered and study periods were relatively short.