E
Ezgi Deniz Batu
Researcher at Hacettepe University
Publications - 151
Citations - 2385
Ezgi Deniz Batu is an academic researcher from Hacettepe University. The author has contributed to research in topics: Medicine & Familial Mediterranean fever. The author has an hindex of 20, co-authored 115 publications receiving 1614 citations. Previous affiliations of Ezgi Deniz Batu include Boston Children's Hospital & University of Health Sciences Antigua.
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Journal ArticleDOI
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Qing Zhou,Hongying Wang,Daniella M. Schwartz,Monique Stoffels,Yong Hwan Park,Yuan Zhang,Dan Yang,Erkan Demirkaya,Masaki Takeuchi,Wanxia Li Tsai,Jonathan J. Lyons,Xiaomin Yu,Claudia Ouyang,Celeste Chen,David T. Chin,Kristien J. M. Zaal,Settara C. Chandrasekharappa,Eric P. Hanson,Zhen Yu,James C. Mullikin,Sarfaraz Hasni,Ingrid E. Wertz,Amanda K. Ombrello,Deborah L. Stone,Patrycja Hoffmann,Anne Jones,Beverly K. Barham,Helen L. Leavis,Annet Van Royen-Kerkof,Cailin H. Sibley,Ezgi Deniz Batu,Ahmet Gül,Richard M. Siegel,Manfred Boehm,Joshua D. Milner,Seza Ozen,Massimo Gadina,Jae Jin Chae,Ronald M. Laxer,Daniel L. Kastner,Ivona Aksentijevich +40 more
TL;DR: A new disease caused by high-penetrance heterozygous germline mutations in TNFAIP3, which encodes the NF-κB regulatory protein A20, in six unrelated families with early-onset systemic inflammation is described, which resembles Behçet's disease.
Journal ArticleDOI
A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease
Florence A. Aeschlimann,Ezgi Deniz Batu,Scott W. Canna,Ellen Go,Ahmet Gül,Patrycja Hoffmann,Helen L. Leavis,Seza Ozen,Daniella M. Schwartz,Deborah L. Stone,Annet Van Royen-Kerkof,Daniel L. Kastner,Ivona Aksentijevich,Ronald M. Laxer +13 more
TL;DR: Early-onset recurrent oral, genital and/or gastrointestinal ulcers are the hallmark feature of HA20, and treatment regimens should be based on disease severity, and cytokine inhibitors are often required to control relapses.
Journal ArticleDOI
Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management.
TL;DR: Although FMF is a relatively well-described AID, there are still a number of unsolved problems about it such as the exact mechanism of the disease, symptomatic heterozygotes and their treatment, and the optimal management of colchicine resistance.
Journal Article
Performance of the new SLICC classification criteria in childhood systemic lupus erythematosus: a multicentre study.
Erdal Sag,Antonella Tartaglione,Ezgi Deniz Batu,Angelo Ravelli,S. M A Khalil,Stephen D. Marks,Seza Ozen +6 more
TL;DR: In the paediatric series, the SLICC criteria showed better sensitivity and led to fewer misclassifications, but were less specific than the ACR criteria.
Journal ArticleDOI
A Case Series of Adenosine Deaminase 2-deficient Patients Emphasizing Treatment and Genotype-phenotype Correlations.
Ezgi Deniz Batu,Omer Karadag,Ekim Z. Taskiran,Umut Kalyoncu,Ivona Aksentijevich,Mehmet Alikasifoglu,Seza Ozen +6 more
TL;DR: The characteristics of 6 DADA2 patients and their response to various therapies are presented and monogenic disorders may cause a PAN-like vasculopathy.