F
Florencia Bullrich
Researcher at Thomas Jefferson University
Publications - 32
Citations - 15843
Florencia Bullrich is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Gene & Chronic lymphocytic leukemia. The author has an hindex of 26, co-authored 32 publications receiving 15253 citations. Previous affiliations of Florencia Bullrich include University of California, San Diego.
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Journal ArticleDOI
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
George A. Calin,Calin Dan Dumitru,Masayoshi Shimizu,Roberta Bichi,Simona Zupo,Evan Noch,Hansjuerg Aldler,Sashi Rattan,Michael J. Keating,Kanti R. Rai,Laura Z. Rassenti,Thomas J. Kipps,Massimo Negrini,Florencia Bullrich,Carlo M. Croce +14 more
TL;DR: Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (≈68%) of CLL cases.
Journal ArticleDOI
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
George A. Calin,Cinzia Sevignani,Calin Dan Dumitru,Terry Hyslop,Evan Noch,Sai Yendamuri,Masayoshi Shimizu,Sashi Rattan,Florencia Bullrich,Massimo Negrini,Massimo Negrini,Carlo M. Croce +11 more
TL;DR: These data provide a catalog of miR genes that may have roles in cancer and argue that the full complement of miRs in a genome may be extensively involved in cancers.
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MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
George A. Calin,Chang Gong Liu,Cinzia Sevignani,Manuela Ferracin,Nadia Felli,Nadia Felli,Calin Dan Dumitru,Masayoshi Shimizu,Amelia Cimmino,Simona Zupo,Marielia Dono,Marie Dell'Aquila,Hansjuerg Alder,Laura Z. Rassenti,Thomas J. Kipps,Florencia Bullrich,Florencia Bullrich,Massimo Negrini,Carlo M. Croce,Carlo M. Croce +19 more
TL;DR: Genomewide expression profiling of miRNAs in human B cell chronic lymphocytic leukemia (CLL) is reported by using a microarray containing hundreds of human precursor and mature miRNA oligonucleotide probes, suggesting that miRNA expression patterns have relevance to the biological and clinical behavior of this leukemia.
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An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues
Chang Gong Liu,George A. Calin,Brian Meloon,Nir Gamliel,Cinzia Sevignani,Manuela Ferracin,Calin Dan Dumitru,Masayoshi Shimizu,Simona Zupo,Mariella Dono,Hansjuerg Alder,Florencia Bullrich,Massimo Negrini,Massimo Negrini,Carlo M. Croce +14 more
TL;DR: A recently developed methodology for miRNA gene expression profiling based on the development of a microchip containing oligonucleotides corresponding to 245 miRNAs from human and mouse genomes is described.
Journal ArticleDOI
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Teresa Fernandes-Alnemri,Robert C. Armstrong,Joseph F. Krebs,Srinivasa M. Srinivasula,Lijuan Wang,Florencia Bullrich,Lawrence C. Fritz,Joseph A. Trapani,Kevin J. Tomaselli,Gerald Litwack,Emad S. Alnemri +10 more
TL;DR: The cloning of two novel ASCPs from human Jurkat T-lymphocytes are described, containing a QACQG pentapeptide instead of the QACRG present in ail known ASCPs, and the presence of the FADD-like domains in Mch4 and Mch5 suggests a role for these proteases in the Fas-apoptotic pathway.