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Chang Gong Liu
Researcher at Ohio State University
Publications - Â 89
Citations - Â 47692
Chang Gong Liu is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Gene expression profiling. The author has an hindex of 61, co-authored 89 publications receiving 45859 citations. Previous affiliations of Chang Gong Liu include Thomas Jefferson University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
MicroRNA gene expression deregulation in human breast cancer.
Marilena V. Iorio,Manuela Ferracin,Chang Gong Liu,Angelo Veronese,Riccardo Spizzo,Silvia Sabbioni,Eros Magri,Massimo Pedriali,Muller Fabbri,Manuela Campiglio,Sylvie Ménard,Juan P. Palazzo,Anne L. Rosenberg,Piero Musiani,Stefano Volinia,Italo Nenci,George A. Calin,Patrizia Querzoli,Massimo Negrini,Carlo M. Croce +19 more
TL;DR: It is shown that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer, and the overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated mi RNAs being mir-125b, mir-145, mir -21, and mir-155.
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miR-15 and miR-16 induce apoptosis by targeting BCL2.
Amelia Cimmino,George A. Calin,Muller Fabbri,Marilena V. Iorio,Manuela Ferracin,Masayoshi Shimizu,Sylwia E. Wojcik,Rami I. Aqeilan,Simona Zupo,Mariella Dono,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Massimo Negrini,Carlo M. Croce +17 more
TL;DR: It is demonstrated thatmiR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate BCL2 at a posttranscriptional level and are natural antisense B cl2 interactors that could be used for therapy of Bcl1-overexpressing tumors.
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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara,Natasha J. Caplen,Elise D. Bowman,Masahiro Seike,Kensuke Kumamoto,Ming Yi,Robert M. Stephens,Aikou Okamoto,Jun Yokota,Tadao Tanaka,George A. Calin,Chang Gong Liu,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
Journal ArticleDOI
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
George A. Calin,Manuela Ferracin,Manuela Ferracin,Amelia Cimmino,Gianpiero Di Leva,Masayoshi Shimizu,Sylwia E. Wojcik,Marilena V. Iorio,Rosa Visone,Nurettin Ilfer Sever,Muller Fabbri,Muller Fabbri,Rodolfo Iuliano,Tiziana Palumbo,Flavia Pichiorri,Claudia Roldo,Ramiro Garzon,Cinzia Sevignani,Laura Z. Rassenti,Hansjuerg Alder,Stefano Volinia,Chang Gong Liu,Thomas J. Kipps,Massimo Negrini,Carlo M. Croce +24 more
TL;DR: A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.