F
Foram Vyas
Researcher at Princess Margaret Cancer Centre
Publications - 9
Citations - 346
Foram Vyas is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications receiving 93 citations. Previous affiliations of Foram Vyas include University of Toronto.
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Journal ArticleDOI
GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer
Grainne M. O'Kane,Barbara Grünwald,Barbara Grünwald,Gun-Ho Jang,Mehdi Masoomian,Sarah Picardo,Robert C. Grant,Robert C. Grant,Robert E. Denroche,Amy Zhang,Yifan Wang,Yifan Wang,Bernard Lam,Paul M. Krzyzanowski,Illinca M. Lungu,John M. S. Bartlett,Melanie Peralta,Foram Vyas,Rama Khokha,James Joseph Biagi,Dianne Chadwick,Stephanie Ramotar,Shawn Hutchinson,Anna Dodd,Julie M. Wilson,Faiyaz Notta,Faiyaz Notta,George Zogopoulos,George Zogopoulos,Steven Gallinger,Jennifer J. Knox,Sandra Fischer +31 more
TL;DR: The basal-like subtype is chemoresistant and can be distinguished from classical PDAC by GATA6 expression, which was prognostic and predicted the subtypes with sensitivity and specificity.
Journal ArticleDOI
Spatially confined sub-tumor microenvironments in pancreatic cancer.
Barbara Grünwald,Antoine Devisme,Geoffroy Andrieux,Foram Vyas,Kazeera Aliar,Curtis W. McCloskey,Andrew Macklin,Gun Ho Jang,Robert E. Denroche,Joan Miguel Romero,Prashant Bavi,Peter Bronsert,Faiyaz Notta,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Laura Tamblyn,Molly Udaskin,Nikolina Radulovich,Sandra Fischer,Melanie Boerries,Melanie Boerries,Steven Gallinger,Thomas Kislinger,Thomas Kislinger,Rama Khokha,Rama Khokha +26 more
TL;DR: In this paper, the authors deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multi-OMICs with clinical data and patient-derived preclinical models.
Journal ArticleDOI
A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.
Joan Miguel Romero,Joan Miguel Romero,Barbara Grünwald,Gun-Ho Jang,Prashant Bavi,Prashant Bavi,Aaditeya Jhaveri,Mehdi Masoomian,Sandra Fischer,Sandra Fischer,Sandra Fischer,Amy Zhang,Robert E. Denroche,Ilinca Lungu,Angela De Luca,John M. S. Bartlett,Jing Xu,Niandong Li,Sharon Dhaliwal,Sheng-Ben Liang,Dianne Chadwick,Foram Vyas,Peter Bronsert,Rama Khokha,Tracy L. McGaha,Tracy L. McGaha,Faiyaz Notta,Pamela S. Ohashi,Pamela S. Ohashi,Susan J. Done,Susan J. Done,Grainne M. O'Kane,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Jennifer J. Knox,Ashton A. Connor,Yifan Wang,Yifan Wang,George Zogopoulos,George Zogopoulos,Steven Gallinger +41 more
TL;DR: A conserved 4-chemokine signature marks resectable and metastatic PDAC tumors with an active antitumor phenotype, which could have implications for the appropriate selection of PDAC patients in immunotherapy trials.
Posted ContentDOI
Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology
Barbara Grünwald,Antoine Devisme,Geoffroy Andrieux,Geoffroy Andrieux,Foram Vyas,Foram Vyas,Kazeera Aliar,Curtis W. McCloskey,Andrew Macklin,Gun Ho Jang,Robert E. Denroche,Joan Miguel Romero,Prashant Bavi,Prashant Bavi,Peter Bronsert,Faiyaz Notta,Faiyaz Notta,Faiyaz Notta,Grainne M. O'Kane,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Jennifer J. Knox,Laura Tamblyn,Nikolina Radulovich,Sandra Fischer,Melanie Boerries,Melanie Boerries,Steven Gallinger,Thomas Kislinger,Thomas Kislinger,Rama Khokha,Rama Khokha +32 more
TL;DR: In this article, the authors deconvolute regional heterogeneity in the human PDAC tumor microenvironment (TME), a long-standing obstacle, to define precise stromal contributions to PDAC progression.
Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer.
Grainne M. O'Kane,Barbara Grünwald,Gun Ho Jang,Mehdi Masoomian,Sarah Picardo,Robert M. Grant,Robert E. Denroche,Amy Zhang,Yifan Yang,Jessica Miller,Bernard C.-H. Lam,Paul M. Krzyzanowski,Ilinca Lungu,John M. S. Bartlett,Melanie Peralta,Foram Vyas,Rama Khokha,James Joseph Biagi,Dianne Chadwick,Stephanie Ramotar,Shawn Hutchinson,Anna Dodd,Julie M. Wilson,Faiyaz Notta,George Zogopoulos,Steven Gallinger,Jennifer J. Knox,Sandra Fischer +27 more