Prashant Bavi

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.

TL;DR: Results suggest that the PI3K/AKT pathway may be a potential target for therapeutic intervention in DLBCL.

TL;DR: Signatures were faithfully propagated from primaries to matched metastases, implying their stability during carcinogenesis, and signature-based subtyping may guide personalized therapy of PDAC in the context of biomarker-driven prospective trials.

TL;DR: Clinical and genetic findings suggest that ADAMTS17 plays a role in crystalline lens zonules and connective tissue formation and that mutations in ADAM TS17 are sufficient to produce some of the main features typically described in Weill-Marchesani syndrome.