Forrest Spencer

TL;DR: The default ad hoc adjustment, provided as part of the Affymetrix system, can be improved through the use of estimators derived from a statistical model that uses probe sequence information, which greatly improves the performance of the technology in various practical applications.

TL;DR: A consortium of ten laboratories from the Washington, DC–Baltimore, USA, area was formed to compare data obtained from three widely used platforms using identical RNA samples to demonstrate that there are relatively large differences in data obtained in labs using the same platform, but that the results from the best-performing labs agree rather well.

TL;DR: A novel probabilistic metric is created that takes advantage of the high density of data, including both the presence and absence of individual associations, to provide a measure of the relative confidence of each potential protein-protein interaction and organized proteins into coherent multisubunit complexes using hierarchical clustering.

TL;DR: A model of viral transformation in which Tax targets TXBP181, thereby abrogating a mitotic checkpoint is proposed, which proposes a phenotype consistent with a loss of HsMAD1 function.

TL;DR: It is shown that down-regulation or genetic disruption of the two major candidate CIN genes identified in previous studies also resulted in abnormal sister chromatid cohesion in human cells, suggesting that defective sister chrom atid cohesion as a result of somatic mutations may represent a major cause of chromosome instability in human cancers.