Frank C. P. Holstege

TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.

TL;DR: A novel probabilistic metric is created that takes advantage of the high density of data, including both the presence and absence of individual associations, to provide a measure of the relative confidence of each potential protein-protein interaction and organized proteins into coherent multisubunit complexes using hierarchical clustering.

TL;DR: A doxycycline‐regulated form of the H1 promoter of RNA polymerase III that allows the inducible knockdown of gene expression by small interfering RNAs (siRNAs) is designed and targeted β‐catenin in colorectal cancer cells as a proof‐of‐principle.

TL;DR: DNA microarray gene-expression profiling can detect lymph node metastases for primary head and neck squamous cell carcinomas that arise in the oral cavity and oropharynx and shows that the metastatic state can be deciphered from the primary tumor gene- expression pattern and that treatment can be substantially improved.

TL;DR: Monitoring mRNA expression genome-wide, for individual deletions of one-quarter of yeast genes, shows a surprisingly high abundance of gene-specific repressors, suggesting that yeast chromatin is not as generally restrictive to transcription as is often assumed.