F
Franca Viola
Researcher at University of Turin
Publications - 71
Citations - 1315
Franca Viola is an academic researcher from University of Turin. The author has contributed to research in topics: Cyclase & 2,3-Oxidosqualene. The author has an hindex of 19, co-authored 71 publications receiving 1257 citations.
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Journal ArticleDOI
Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles.
Paola Milla,Karin Athenstaedt,Franca Viola,Simonetta Oliaro-Bosso,Sepp D. Kohlwein,Guenther Daum,Gianni Balliano +6 more
TL;DR: In this article, Xenstaedt et al. showed that Erg7p is almost exclusively associated with this compartment as shown by analysis of enzymatic activity, Western blot analysis, and in vivo localization of erg7p-GFP.
Journal ArticleDOI
The squalene-2,3-epoxide cyclase as a model for the development of new drugs
Luigi Cattel,Maurizio Ceruti,Franca Viola,Laura Delprino,Gianni Balliano,Albert Duriatti,Pierrette Bouvier-Navé +6 more
TL;DR: 2-aza-2,3-dihydrosqualene and its derivatives strongly inhibited the cyclases, the site of the enzyme responsible for binding to the inhibitor is quite sensitive to the steric hindrance, and the degree of the inhibitory activity is greater in higher plants than in rat liver or fungi.
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Synthesis and biological activity of azasqualenes, bis-azasqualenes and derivatives
TL;DR: AzasQualenes, bis-azasqualenes and derivatives, designed as inhibitors of squalene 2,3-epoxide cyclase, a key enzyme in sterol biosynthesis, were synthesized and their in vitro activities against a variety of yeasts, fungi, gram-positive and gram-negative bacteria were determined.
Journal ArticleDOI
Regulation of HMGCoA reductase activity by policosanol and octacosadienol, a new synthetic analogue of octacosanol.
Simonetta Oliaro-Bosso,Emanuela Calcio Gaudino,Stefano Mantegna,Enrico Giraudo,Claudia Meda,Franca Viola,Giancarlo Cravotto +6 more
TL;DR: Octacosadienol was as effective as policosanol in inhibiting the upregulation of HMG coA reductase, in inducing the phosphorylation of AMPK and in downregulating the HMGCoA reduCTase mRNA.
Journal ArticleDOI
2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase.
TL;DR: 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2, 3-oxidosqualene (SO) cyclase was obtained by total synthesis and was designed to mimic the C-8 carbonium ion formed during SO cyclization.