抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

1: Magnetic Particles: Preparation, Properties and Applications: M. Ozaki. 2: Maghemite (gamma-Fe2O3): A Versatile Magnetic Colloidal Material C.J. Serna, M.P. Morales. 3: Dynamics of Adsorption and Oxidation of Organic Molecules on Illuminated Titanium Dioxide Particles Immersed in Water M.A. Blesa, R.J. Candal, S.A. Bilmes. 4: Colloidal Aggregation in Two-Dimensions A. Moncho-Jorda, F. Martinez-Lopez, M.A. Cabrerizo-Vilchez, R. Hidalgo Alvarez, M. Quesada-PMerez. 5: Kinetics of Particle and Protein Adsorption Z. Adamczyk.

Surface and Colloid Science

In the past decade, there have been exciting developments in the field of lithium ion batteries as energy storage devices, resulting in the application of lithium ion batteries in areas ranging from small portable electric devices to large power systems such as hybrid electric vehicles. However, the maximum energy density of current lithium ion batteries having topatactic chemistry is not sufficient to meet the demands of new markets in such areas as electric vehicles. Therefore, new electrochemical systems with higher energy densities are being sought, and metal-air batteries with conversion chemistry are considered a promising candidate. More recently, promising electrochemical performance has driven much research interest in Li-air and Zn-air batteries. This review provides an overview of the fundamentals and recent progress in the area of Li-air and Zn-air batteries, with the aim of providing a better understanding of the new electrochemical systems.

https://www.onlinelibrary.wiley.com/doi/epdf/10.1002/aenm.201000010

Metal–Air Batteries with High Energy Density: Li–Air versus Zn–Air

: The unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio. Harmonic force fields are obtained using Density Functional Theory (DFT), MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set. DFT calculations use the Local Spin Density Approximation (LSDA), BLYP, and Becke3LYP (B3LYP) density functionals. Mid-IR spectra predicted using LSDA, BLYP, and B3LYP force fields are of significantly different quality, the B3LYP force field yielding spectra in clearly superior, and overall excellent, agreement with experiment. The MP2 force field yields spectra in slightly worse agreement with experiment than the B3LYP force field. The SCF force field yields spectra in poor agreement with experiment.The basis set dependence of B3LYP force fields is also explored: the 6-31G* and TZ2P basis sets give very similar results while the 3-21G basis set yields spectra in substantially worse agreements with experiment. jg

Ab initio calculation of vibrational absorption and circular dichroism spectra using density functional force fields

The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to spatial gradients of signalling activities, which guide pivotal intracellular processes and tightly regulate signal propagation across a cell. Computational models provide insights into the complex relationships between the stimuli and the cellular responses, and reveal the mechanisms that are responsible for signal amplification, noise reduction and generation of discontinuous bistable dynamics or oscillations.

/pdf/cell-signalling-dynamics-in-time-and-space-1kenz3nw5d.pdf

Cell-signalling dynamics in time and space

http://www.metabolismo.biz/web/wp-content/uploads/Glicogen-two-dimensional.pdf

Physical constraints in the synthesis of glycogen that influence its structural homogeneity: a two-dimensional approach.

Induced reactant adsorption in metal—polyelectrolyte systems: pulse polarographic study

/pdf/a-spectrophotometer-based-diffusivity-assay-reveals-that-2jc7e3gr4t.pdf

A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects.

The new electroanalytical technique AGNES (Absence of Gradients and Nernstian Equilibrium Stripping) has been applied to follow Pb2+ complexation to Purified Aldrich Humic Acid. A refined methodology of AGNES, allowing considerably larger gains, reached free metal ion concentrations down to subnanomolar values in a reasonable deposition time due to the lability and mobility of these complexes. Further insights into the meaning of the binding data, fitted to a NICA (Non Ideal Competitive Adsorption) isotherm, can be obtained with the concept of conditional affinity spectrum (CAS). For this purpose, we present the analytical expression for the CAS of NICA isotherm and show the CAS distributions for the Pb binding at fixed pH. Results reveal that the underlying spectra of each elementary distribution of the bimodal NICA evolve with pH yielding different overlapping and nonsymmetrical distributions. A non-negligible occupation of phenolic and carboxylic sites by Pb2+ takes place in the range of 4 < pH < 9.

Conditional Affinity Spectra of Pb2+−Humic Acid Complexation from Data Obtained with AGNES

The structure of the electric double layer in contact with discrete and continuously charged planar surfaces is studied within the framework of the primitive model through Monte Carlo simulations. Three different discretization models are considered together with the case of uniform distribution. The effect of discreteness is analyzed in terms of charge density profiles. For point surface groups, a complete equivalence with the situation of uniformly distributed charge is found if profiles are exclusively analyzed as a function of the distance to the charged surface. However, some differences are observed moving parallel to the surface. Significant discrepancies with approaches that do not account for discreteness are reported if charge sites of finite size placed on the surface are considered.

/pdf/effect-of-the-surface-charge-discretization-on-electric-4q638nv8i3.pdf

Francesc Mas

Papers

Physical constraints in the synthesis of glycogen that influence its structural homogeneity: a two-dimensional approach.

Induced reactant adsorption in metal—polyelectrolyte systems: pulse polarographic study

A spectrophotometer-based diffusivity assay reveals that diffusion hindrance of small molecules in extracellular matrix gels used in 3D cultures is dominated by viscous effects.

Conditional Affinity Spectra of Pb2+−Humic Acid Complexation from Data Obtained with AGNES

Effect of the surface charge discretization on electric double layers: a Monte Carlo simulation study.