F
Francesca De Giorgio
Researcher at UCL Institute of Neurology
Publications - 4
Citations - 69
Francesca De Giorgio is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: TARDBP & RNA splicing. The author has an hindex of 2, co-authored 4 publications receiving 49 citations. Previous affiliations of Francesca De Giorgio include University College London.
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Journal ArticleDOI
Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis
TL;DR: Two key types of amyotrophic lateral sclerosis mouse models are compared: transgenic mice and those that express genes at physiological levels, exploring the advantages of each type for studying pathomechanisms and comparing the phenotypes for genes in which the two classes of model exist.
Journal ArticleDOI
TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.
Journal ArticleDOI
Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models
Anny Devoy,Georgia Price,Francesca De Giorgio,Rosie K. A. Bunton-Stasyshyn,David C. Thompson,Samanta Gasco,Alasdair J Allan,Gemma F. Codner,Remya R. Nair,Charlotte Tibbit,Ross McLeod,Zeinab Ali,Judith Noda,Alessandro Marrero-Gagliardi,José M. Brito-Armas,Muhammet M. Öztürk,Michelle Simon,Edward O’Neill,Sam Bryce-Smith,Jackie Harrison,Gemma Atkins,Silvia Corrochano,Michelle Stewart,Lydia Teboul,Abraham Acevedo-Arozena,Elizabeth M. C. Fisher,Thomas J. Cunningham +26 more
TL;DR: In this paper, the mouse genomic region of Sod1, Tardbp (TDP-43), and Fus was replaced with their human orthologues, preserving human protein biochemistry and splicing with exons and introns intact.
Posted ContentDOI
Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS
Anny Devoy,Georgia Price,Francesca De Giorgio,Rosie K. A. Bunton-Stasyshyn,David C. Thompson,Samanta Gasco,Alasdair J Allan,Gemma F. Codner,Remya R. Nair,Charlotte Tibbit,Ross McLeod,Zeinab Ali,Judith Noda,Alessandro Marrero-Gagliardi,José M. Brito-Armas,Michelle Simon,Edward O’Neill,Jackie Harrison,Gemma Atkins,Silvia Corrochano,Michelle Stewart,Lydia Teboul,Abraham Acevedo-Arozena,Elizabeth M. C. Fisher,Thomas J. Cunningham +24 more
TL;DR: In this article, the authors have created three next-generation genomically humanised knock-in mouse models for ALS/FTD research, by replacing the entire mouse coding region of Sod1, Tardbp (TDP-43) and Fus, with their human orthologues to preserve human protein biochemistry, with exons and introns intact.