L
Lydia Teboul
Researcher at Medical Research Council
Publications - 92
Citations - 7235
Lydia Teboul is an academic researcher from Medical Research Council. The author has contributed to research in topics: Gene & Genome editing. The author has an hindex of 31, co-authored 81 publications receiving 5910 citations. Previous affiliations of Lydia Teboul include National Institute for Medical Research & University of Nice Sophia Antipolis.
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Journal ArticleDOI
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.
Maximilian Haeussler,Kai Schönig,Helene Eckert,Alexis Eschstruth,Joffrey Mianné,Jean-Baptiste Renaud,Sylvie Schneider-Maunoury,Alena Shkumatava,Lydia Teboul,Jim Kent,Jean-Stéphane Joly,Jean-Paul Concordet +11 more
TL;DR: It is found that the optimal on-target efficiency prediction model strongly depends on whether the guide RNA is expressed from a U6 promoter or transcribed in vitro, and it is demonstrated that the best predictions can significantly reduce the time spent on guide screening.
Journal ArticleDOI
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
Journal ArticleDOI
NAADP mobilizes calcium from acidic organelles through two-pore channels
Peter J. Calcraft,Margarida Ruas,Zui Pan,Xiaotong Cheng,Abdelilah Arredouani,Xuemei Hao,Xuemei Hao,Jisen Tang,Katja Rietdorf,Lydia Teboul,Kai Ting Chuang,Pei-Hui Lin,Rui Xiao,Chunbo Wang,Yingmin Zhu,Yakang Lin,Christopher N. Wyatt,John Parrington,Jianjie Ma,A. Mark Evans,Antony Galione,Michael X. Zhu +21 more
TL;DR: It is shown that two-pore channels (TPCs) comprise a family of NAADP receptors, with human TPC1 and chicken TPCN3 being expressed on endosomal membranes, andhuman TPC2 on lysosome membranes when expressed in HEK293 cells, which will advance the understanding of the physiological role ofNAADP.
Journal ArticleDOI
Overexpression of Fto leads to increased food intake and results in obesity.
Chris Church,Lee Moir,Fiona McMurray,Christophe Girard,Gareth Banks,Lydia Teboul,Sara Wells,Jens C. Brüning,Patrick M. Nolan,Frances M. Ashcroft,Roger D. Cox +10 more
TL;DR: This study provides the first direct evidence that increased Fto expression causes obesity in mice and shows here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and fat mass, irrespective of whether mice are fed a standard or a high-fat diet.
Journal Article
p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
Laurent Nguyen,Arnaud Besson,J Ik-Tsen Heng,Carol Schuurmans,Lydia Teboul,C. Parras,Anna Philpott,Justin M. Roberts,François Guillemot +8 more
TL;DR: It is shown that the cyclin-dependent kinase inhibitor p27Kip1 plays an important role in neurogenesis in the mouse cerebral cortex, by promoting the differentiation and radial migration of cortical projection neurons.