F
Francesco Ortuso
Researcher at Magna Græcia University
Publications - 150
Citations - 4834
Francesco Ortuso is an academic researcher from Magna Græcia University. The author has contributed to research in topics: Docking (molecular) & Monoamine oxidase. The author has an hindex of 36, co-authored 143 publications receiving 4141 citations. Previous affiliations of Francesco Ortuso include University of Rome Tor Vergata & University of Calabria.
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Journal ArticleDOI
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Franco Chimenti,Rossella Fioravanti,Adriana Bolasco,Paola Chimenti,Daniela Secci,Francesca Rossi,Matilde Yáñez,Francisco Orallo,Francesco Ortuso,Stefano Alcaro +9 more
TL;DR: The docking technique provided new insight on the inhibition mechanism and the rational drug design of more potent/selective hMAO inhibitors based on the chalcone scaffold.
Journal ArticleDOI
Synthesis, Molecular Modeling, and Selective Inhibitory Activity against Human Monoamine Oxidases of 3-Carboxamido-7-Substituted Coumarins†
Franco Chimenti,Daniela Secci,Adriana Bolasco,Paola Chimenti,Bruna Bizzarri,Arianna Granese,Simone Carradori,Matilde Yáñez,Francisco Orallo,Francesco Ortuso,Stefano Alcaro +10 more
TL;DR: To better understand the enzyme-inhibitor interaction and to explain the selectivity of the most active compounds toward hMAOs, molecular modeling studies were carried out on new, high resolution, hMAO-A and h MAO-B crystallographic structures.
Journal ArticleDOI
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.
Alexandra Gaspar,Tiago H. Silva,Matilde Yáñez,Dolores Viña,Franscisco Orallo,Francesco Ortuso,Eugenio Uriarte,Stefano Alcaro,Fernanda Borges +8 more
TL;DR: The differential analysis of the solvation effects among the chromone isomers gave additional insight about the superior outline of the 3-substituted chromone derivatives, which act preferably as MAO-B inhibitors.
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Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: Extraction, biological analysis, and computational study
Franco Chimenti,Filippo Cottiglia,Leonardo Bonsignore,Laura Casu,Mariano Casu,Costantino Floris,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Olivia Befani,Paola Turini,Stefano Alcaro,Francesco Ortuso,G. Trombetta,and Alberto Loizzo,Irene Guarino +16 more
TL;DR: The methanol extract from Hypericum hircinum leaves exhibited in vitro inhibition of monoamine oxidases (MAO) and quercetin was the only compound with a selective inhibitory activity against MAO-A, with an IC50 value of 0.010 microM.
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Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives.
Franco Chimenti,Elias Maccioni,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Olivia Befani,Paola Turini,Stefano Alcaro,Francesco Ortuso,Roberto Cirilli,Francesco La Torre,Maria Cristina Cardia,Simona Distinto +13 more
TL;DR: The docking study was carried out using several computational approaches with the aim of proposing possible binding modes of the MAO enantioselective compounds 1 and 4, and found the selectivity of the (-)-(S)-1 enantiomer against MAO-B increases twice and a half, while the selectability of the (+)- (S)-4 enantiomers againstMAO-A triples increases three times.