M
Matilde Yáñez
Researcher at University of Santiago de Compostela
Publications - 7
Citations - 426
Matilde Yáñez is an academic researcher from University of Santiago de Compostela. The author has contributed to research in topics: Chemical synthesis & Docking (molecular). The author has an hindex of 5, co-authored 7 publications receiving 386 citations. Previous affiliations of Matilde Yáñez include University of A Coruña.
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Journal ArticleDOI
Synthesis, Molecular Modeling, and Selective Inhibitory Activity against Human Monoamine Oxidases of 3-Carboxamido-7-Substituted Coumarins†
Franco Chimenti,Daniela Secci,Adriana Bolasco,Paola Chimenti,Bruna Bizzarri,Arianna Granese,Simone Carradori,Matilde Yáñez,Francisco Orallo,Francesco Ortuso,Stefano Alcaro +10 more
TL;DR: To better understand the enzyme-inhibitor interaction and to explain the selectivity of the most active compounds toward hMAOs, molecular modeling studies were carried out on new, high resolution, hMAO-A and h MAO-B crystallographic structures.
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Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids.
Santiago Vilar,Elias Quezada,Lourdes Santana,Eugenio Uriarte,Matilde Yáñez,Nuria Fraiz,Carlos Alcaide,Ernesto Cano,Francisco Orallo +8 more
TL;DR: The results suggest that these novel compounds may have potential as structural templates for the design and subsequent development of new vasodilatory and platelet antiaggregatory drugs.
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Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.
Franco Chimenti,Elias Maccioni,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Simone Carradori,Stefano Alcaro,Francesco Ortuso,Matilde Yáñez,Francisco Orallo,Roberto Cirilli,Rosella Ferretti,Francesco La Torre +13 more
TL;DR: A series of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones have been investigated for their ability to inhibit selectively the activity of the human A and B isoforms of monoamine oxidase (MAO).
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New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities.
Tamara Costas,Pedro Besada,Alessandro Piras,Laura Acevedo,Matilde Yáñez,Francisco Orallo,Reyes Laguna,Carmen Terán,Carmen Terán +8 more
TL;DR: Analysis of biological data revealed the silyl ethers and N,O-dibenzyl derivatives (6g-i) as the most active compounds as the new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents.
Journal ArticleDOI
Design, Synthesis, and Vasorelaxant and Platelet Antiaggregatory Activities of Coumarin—Resveratrol Hybrids.
Santiago Vilar,Elias Quezada,Lourdes Santana,Eugenio Uriarte,Matilde Yáñez,Nuria Fraiz,Carlos Alcaide,Ernesto Cano,Francisco Orallo +8 more
TL;DR: In this paper, the coumarin-resveratrol hybrid 4 and its dimethoxy derivative 3 were synthesized by a very direct synthetic route involving a Pechmann procedure.