Elias Maccioni

TL;DR: The results demonstrate that CPTH2 is a novel HAT inhibitor modulating Gcn5p network in vitro and in vivo, and demonstrated a specific chemical-genetic interaction betweenCPTH2 and HAT GCN5p, indicating that CP TH2 inhibits the Gcn 5p dependent functional network.

TL;DR: The docking study was carried out using several computational approaches with the aim of proposing possible binding modes of the MAO enantioselective compounds 1 and 4, and found the selectivity of the (-)-(S)-1 enantiomer against MAO-B increases twice and a half, while the selectability of the (+)- (S)-4 enantiomers againstMAO-A triples increases three times.

TL;DR: A series of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones have been investigated for their ability to inhibit selectively the activity of the human A and B isoforms of monoamine oxidase (MAO).

TL;DR: A high throughput in silico screening of commercially available molecules databases by merging ligand- and structure-based approaches by means of docking experiments succeeded in retrieving a new promising scaffold for G-quadruplex binders characterized by a psoralen moiety.

TL;DR: A novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity is reported and in general they were shown to induce low cytotoxic effects.