Francine Grondin

TL;DR: It is demonstrated for the first time that furin is an authentic and adaptive TGF-beta1-converting enzyme whereas other members of the PC family might substitute or supplement furin activity.

TL;DR: It is demonstrated herein that the levels of fur mRNA, encoding furin, are remarkably increased upon hypoxic challenge, and a new facet of the physiological consequences of hypoxia/HIF-1 is unveiled, through enhanced furin-induced proteolytic processing/activation of proproteins known to be involved in tumorigenesis.

TL;DR: The findings clearly show that the activation of the p42/p44 MAPK pathway is involved in fur gene expression and led us to propose a co-operative model whereby TGFβ1-induced receptor activation stimulates not only a Smad pathway but also a parallel p42-p44MAPK pathway that targets Smad2 for an increased nuclear translocation and enhanced fur gene transactivation.

TL;DR: The results taken collectively indicate that the 7.5% chitosan formula maintained adequate cholesterol homeostasis in rats, despite a greatly increased intake of cholesterol.

TL;DR: It is reported that low oxygen concentrations and TNFα enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 (HIF-1) to the 5′ promoter region, which suggests a mechanism by which TACE is increased in RA-affected joints.