F
Francisco Antequera
Researcher at Spanish National Research Council
Publications - 21
Citations - 3354
Francisco Antequera is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: CpG site & DNA replication. The author has an hindex of 17, co-authored 19 publications receiving 3288 citations. Previous affiliations of Francisco Antequera include Research Institute of Molecular Pathology & Western General Hospital.
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Journal ArticleDOI
Number of CpG islands and genes in human and mouse
Francisco Antequera,Adrian Bird +1 more
TL;DR: Analysis of a selection of genes suggests that both human and mouse are losing CpG islands over evolutionary time due to de novo methylation in the germ line followed by C pG loss through mutation, which appears to be more rapid in rodents.
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High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.
TL;DR: It is suggested that mutation-like gene inactivation due to CpG island methylation is widespread in many cell lines and could explain the loss of cell type-specific functions in culture.
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Structure, function and evolution of CpG island promoters
TL;DR: The finding that DNA replication initiates at CpG islands in vivo suggests that their distinctive properties could be a consequence of such activity and opens the possibility of a coordinated regulation of transcription and replication.
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Initiation of DNA replication at CpG islands in mammalian chromosomes
TL;DR: The results imply that CpG islands are initiation sites for both transcription and DNA replication, and may represent genomic footprints of replication initiation.
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Specific protection of methylated CpGs in mammalian nuclei
TL;DR: Quantitative analysis of limit digests showed that MspI and another methyl-CpG insensitive enzyme, Tth, have a strong bias against cutting methylated sites in these nuclei, suggesting that resistance to nucleases is mediated by factors that are bound specifically to methylated CpGs.