F
François Fuks
Researcher at Université libre de Bruxelles
Publications - 106
Citations - 15026
François Fuks is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 45, co-authored 94 publications receiving 13690 citations. Previous affiliations of François Fuks include University of Cambridge & Free University of Brussels.
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Journal ArticleDOI
The Polycomb group protein EZH2 directly controls DNA methylation
Emmanuelle Viré,Carmen Brenner,Rachel Deplus,Loïc Blanchon,Mario F. Fraga,Céline Didelot,Lluis Morey,Aleyde Van Eynde,David Bernard,Jean-Marie Vanderwinden,Mathieu Bollen,Manel Esteller,Luciano Di Croce,Yvan de Launoit,Yvan de Launoit,François Fuks +15 more
TL;DR: The results suggest that EZH2 serves as a recruitment platform for DNA methyltransferases, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems.
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The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation
TL;DR: It is shown that MeCP2 associates with histone methyltransferase activity in vivo and that this activity is directed against Lys9 of histone H3, and this activity coincides with an increase in H3 Lys9methylation.
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DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
TL;DR: A transcriptional repression domain in Dnmt1 is identified that functions, at least partly, by recruiting histone deacetylase activity and shows homology to the repressor domain of the trithorax-related protein HRX (also known as MLL and ALL-1).
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Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
Luciano Di Croce,Veronica A. Raker,Massimo Corsaro,Francesco Fazi,Mirco Fanelli,Mirco Fanelli,Mario Faretta,François Fuks,Francesco Lo Coco,Tony Kouzarides,Clara Nervi,Saverio Minucci,Pier Giuseppe Pelicci +12 more
TL;DR: It is reported here that the leukemia-promoting PML-RAR fusion protein induces gene hypermethylation and silencing by recruiting DNA methyltransferases to target promoters and that hyper methylation contributes to its leukemogenic potential.
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The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
TL;DR: The data show a direct connection between the enzymes responsible for DNA methylation and histone methylation, and substantiate the notion of a self-reinforcing repressive chromatin state through the interplay between these two global epigenetic modifications.