F
François Guillou
Publications - 7
Citations - 549
François Guillou is an academic researcher. The author has contributed to research in topics: Plasmodium falciparum & Substrate (chemistry). The author has an hindex of 6, co-authored 7 publications receiving 503 citations.
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Journal ArticleDOI
In vitro models of the intestinal barrier. The report and recommendations of ECVAM Workshop 46. European Centre for the Validation of Alternative methods.
Eric Le Ferrec,Christophe Chesne,Per Artusson,David J. Brayden,Gérard Fabre,Pierre Gires,François Guillou,Monique Rousset,Werner Rubas,Maria-Laura Scarino +9 more
TL;DR: The main aims of the workshop were to seek a consensus on the current models of the intestinal barriers and ways to screen for the movement of drugs across this barrier, and to make useful recommendations for the promotion of the three Rs in this area as discussed by the authors.
Journal ArticleDOI
Selection of a trioxaquine as an antimalarial drug candidate
Frédéric Coslédan,Laurent Fraisse,Alain Pellet,François Guillou,Benjamin Mordmüller,Peter G. Kremsner,Alicia Moreno,Dominique Mazier,J P Maffrand,Bernard Meunier +9 more
TL;DR: One of these molecules, PA1103/SAR116242, is highly active in vitro on several sensitive and resistant strains of Plasmodium falciparum and combined with a good drug profile (preliminary absorption, metabolism, and safety parameters), these data were favorable for the selection of this particular trioxaquine for development as drug candidate.
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An inter-laboratory study to evaluate the effects of medium composition on the differentiation and barrier function of Caco-2 cell lines.
Flavia Zucco,Anne Françoise Batto,Giovanna Bises,Jean Chambaz,Arianna Chiusolo,Rosa Consalvo,Heide S. Cross,Gianni Dal Negro,Isabella De Angelis,Gérard Fabre,François Guillou,Sebastian Hoffman,Loïc Laplanche,Etienne Morel,Martine Pinçon-Raymond,Pilar Prieto,Laura Turco,Giulia Ranaldi,Monique Rousset,Yula Sambuy,Maria Laura Scarino,François Torreilles,Annalaura Stammati +22 more
TL;DR: Caco-2/TC7 cells performed better than the other three cell lines, both in terms of reproducibility and performance, exhibiting low TEER and mannitol passage, and high alkaline phosphatase activity.
Journal ArticleDOI
Contribution of the n-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans
Sylvie Klieber,Sébastien Hugla,Robert Ngo,Catherine Arabeyre-Fabre,Viviane Meunier,Freddy Sadoun,Olivier Fedeli,Martine Rival,Martine Bourrié,François Guillou,Patrick Maurel,Gérard Fabre +11 more
TL;DR: Direct MDZ N-glucuronidation may partly compensate the decrease in MDZ metabolic clearance caused by the addition of the inhibitor, thus potentially leading to underestimation, at least in vitro, of the extent of DDI.
Journal ArticleDOI
In vitro metabolism of ferroquine (ssr97193) in animal and human hepatic models and antimalarial activity of major metabolites on plasmodium falciparum
Wassim Daher,Lydie Pelinski,Sylvie Klieber,Freddy Sadoun,Viviane Meunier,Martine Bourrié,Christophe Biot,François Guillou,Gérard Fabre,Jacques Brocard,Laurent Fraisse,Jean Pierre Maffrand,Jamal Khalife,Daniel Dive +13 more
TL;DR: The metabolic pathway of ferroquine, based on experiments using animal and human hepatic models, is proposed and the activity of the two main metabolites decreased compared with that of feroquine; however, theactivity of the mono-N-demethyl derivative is significantly higher than that of chloroquine on both strains.