F
François Paris
Researcher at University of Nantes
Publications - 103
Citations - 7679
François Paris is an academic researcher from University of Nantes. The author has contributed to research in topics: Apoptosis & Ceramide. The author has an hindex of 34, co-authored 96 publications receiving 6883 citations. Previous affiliations of François Paris include Memorial Sloan Kettering Cancer Center & Centre national de la recherche scientifique.
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Journal ArticleDOI
Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis
Monica Garcia-Barros,François Paris,Carlos Cordon-Cardo,David Lyden,Shahin Rafii,Adriana Haimovitz-Friedman,Zvi Fuks,Richard Kolesnick +7 more
TL;DR: Microvascular damage regulates tumor cell response to radiation at the clinically relevant dose range, indicating that endothelial apoptosis is a homeostatic factor regulating angiogenesis-dependent tumor growth.
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Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice
François Paris,Zvi Fuks,Anthony Kang,Paola Capodieci,Gloria Juan,Desiree Ehleiter,Adriana Haimovitz-Friedman,Carlos Cordon-Cardo,Richard Kolesnick +8 more
TL;DR: It is shown in mouse models that microvascular endothelial apoptosis is the primary lesion leading to stem cell dysfunction, and this study provides a basis for new approaches to prevent radiation damage to the bowel.
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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.
Yutaka Morita,Gloria I. Perez,François Paris,Silvia R.P. Miranda,Desiree Ehleiter,A. Haimovitz-Friedman,Zvi Fuks,Zhihua Xie,John C. Reed,Edward H. Schuchman,Richard Kolesnick,Jonathan L. Tilly +11 more
TL;DR: The sphingomyelin pathway regulates developmental death of oocytes, and sphingosine-1-phosphate provides a new approach to preserve ovarian function in vivo.
Journal ArticleDOI
Ceramide Enables Fas to Cap and Kill
Aida Cremesti,François Paris,Heike Grassmé,Nils Holler,Jürg Tschopp,Zvi Fuks,Erich Gulbins,Richard Kolesnick +7 more
TL;DR: In this paper, the authors show that capping of Fas is essential for optimal function and capping is ceramide-dependent, and they show that the presence of intact sphingolipid-enriched membrane domains may be essential for Fas capping since their disruption with cholesterol-depleting agents abrogated capping.
Journal ArticleDOI
Early Diagenetic Evolution of Bone Phosphate: An X-ray Diffractometry Analysis
Alain Person,Alain Person,Hervé Bocherens,Jean-François Saliège,François Paris,Valéry Zeitoun,Martine Gérard +6 more
TL;DR: In this paper, a new crystallinity index based on the X-ray powder diffractometric pattern of fossil bone carbonate hydroxylapatite is defined, which provides a semi-quantitative way to estimate the diagenetic changes in archaeological and palaeontological bone phosphate.